Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

377 questions · 402 findings · 108 reviews

No studies found 114 · 28.4%GRADE not reported 107 · 26.6%Very low 88 · 21.9%Low 41 · 10.2%Moderate 45 · 11.2%High 7 · 1.7%

Etretinate vs PUVA

Proportion of participants with adverse effects serious or severe enough to have caused withdrawal ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Alitretinoin vs placebo

Proportion of participants with adverse effects serious or severe enough to have caused withdrawal ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Etanercept vs placebo

Proportion of participants with adverse effects serious or severe enough to have caused withdrawal ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Ustekinumab vs placebo

Proportion of participants with adverse effects serious or severe enough to have caused withdrawal ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse effects Time of measurement: 1 to 48 hours after treatment, end of treatment Scale of measurement:not stated · people suffering from high altitude illness
1 finding from 1 review

Imiquimod 5% cream with tazarotene 0.1% gel vs Imiquimod 5% cream alone

Discontinuation of treatment due to side effects ( · participants with melanoma in situ, including lentigo maligna

Imiquimod 5% cream with tazarotene 0.1% gel showed no clear difference in secondary outcome: Discontinuation of treatment because of harms… compared with imiquimod 5% cream alone (low certainty).

1 finding from 1 review

Summary of findings: multimedia education and a co‐intervention vs co‐intervention alone

Medication side effects Mean adverse self‐medication behaviour score (lower scores indicate safer self‐medication behaviour). Scale from: 0 to 40. · patients taking prescribed and over‐the‐counter medications or their carers
1 finding from 1 review

Intervention not reported

Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) · patients with decreasing recall of events during surgery

The review found no eligible studies for this question.

1 finding from 1 review

Anaesthesia depth monitors (BIS and M‐entropy) vs standard monitoring

Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) · patients with prevention of recall of events during surgery

The review found no eligible studies for this question.

1 finding from 1 review

Anaesthesia depth monitors (BIS) vs standard monitoring

Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) · patients with prevention of recall of events during surgery

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) · patients with prevention of recall of events during surgery

The review found no eligible studies for this question.

1 finding from 1 review

Thiopentone and ketamine vs benzodiazepines

Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) · patients with prevention of recall of events during surgery

The review found no eligible studies for this question.

1 finding from 1 review

Application of heat vs application of cold

Adverse events due to treatment Minor adverse events, reported in studies as: exacerbation in pain after treatment; burn as a result of hot‐water immersion, or transient erythema, or adverse effects due to application of ice · people stung accidentally by bluebottle jellyfish (Physalia) and box jellyfish that do not cause Irukandji syndrome (Hawaiian box…

It is very uncertain whether application of heat changes adverse events due to treatment Minor adverse events, reported in… compared with application of cold (very low certainty).

1 finding from 1 review