Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

488 questions · 501 findings · 191 reviews

No studies found 126 · 25.1%GRADE not reported 124 · 24.8%Very low 104 · 20.8%Low 89 · 17.8%Moderate 49 · 9.8%High 9 · 1.8%

Prophylactic valaciclovir (lower dose) vs Prophylactic valaciclovir (higher dose)

Adverse effects · Patients being treated for cancer (acute leukaemia; chemotherapy or stem-cell transplantation)
1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Adverse effects · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)
1 finding from 1 review

Silver diamine fluoride (SDF) vs Other methods (pooled: ART/glass ionomer cement, nano-silver fluoride, sodium fluoride varnish, placebo)

Adverse effects (tooth staining and other side effects) · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)

SDF commonly causes black staining of arrested lesions; only mild, transient adverse events were reported, with no major adverse events (ungraded).

1 finding from 1 review

Intervention not reported

Adverse effects experienced by mother and/or fetus or nursing baby · women with a history of postnatal depression
1 finding from 1 review

Intervention not reported

Adverse effects experienced by mother and/or foetus or nursing baby · women with a history of postnatal depression
1 finding from 1 review

Dose comparison: oestrogen 100 µg patch vs 200 µg patch plus progestogen

Adverse events ‐ specific side effects attributed to oestrogen over 8 months' · women with PMS

It is very uncertain whether dose comparison: oestrogen 100 µg patch changes adverse events ‐ specific side effects attributed to oestrogen over… compared with 200 µg patch plus progestogen (very low certainty).

1 finding from 1 review

Vitamin E + vitamin C vs placebo

Any adverse effects of vitamin supplementation sufficient to stop supplementation · pregnant women

Vitamin C and vitamin E showed no clear difference in any adverse effects of vitamin supplementation sufficient to stop… compared with placebo (moderate certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy combined with laser/cryotherapy vs conventional laser/cryotherapy

Local adverse effects ‐ perioperative retinal haemorrhages (unit of analysis: eyes) · preterm infants with type 1 ROP

It is very uncertain whether anti‐vascular endothelial growth factor therapy combined with… changes local adverse effects ‐ perioperative retinal haemorrhages (unit of… compared with laser/cryotherapy (very low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy vs conventional laser/cryotherapy

Local adverse effects ‐ lens opacity requiring cataract removal (unit of analysis: eyes) · preterm infants with type 1 ROP

It is very uncertain whether anti‐vascular endothelial growth factor therapy changes local adverse effects ‐ lens opacity requiring cataract removal… compared with conventional laser/cryotherapy (very low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy vs conventional laser/cryotherapy

Local adverse effects ‐ corneal opacity requiring corneal transplant (unit of analysis: eyes) · preterm infants with type 1 ROP

It is very uncertain whether anti‐vascular endothelial growth factor therapy changes local adverse effects ‐ corneal opacity requiring corneal transplant… compared with conventional laser/cryotherapy (very low certainty).

1 finding from 1 review