What do systematic reviews say?

Amifostine (intravenous) vs Amifostine (subcutaneous)

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes
  Increased hypotension with intravenous delivery (20% vs 8%; P = 0.007); skin rash (10% vs 22%; P = 0.012) and local pain at injection site (0% vs 8%; P = 0.001) worse with subcutaneous; inconclusive for…
  1 study
  GRADE not reported

Glass ionomer-based sealant vs No sealant (control/no treatment)

The review found no eligible studies for this question.

• Pit and fissure sealants for preventing dental decay in permanent teeth 2017 · Cochrane All outcomes
  Adverse effects not measured.
  Studies not reported
  No studies found

Beta‐carotene vs placebo

• Antioxidant vitamin and mineral supplements for preventing age‐related macular degeneration 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  High

Vitamin C vs placebo

The review found no eligible studies for this question.

• Antioxidant vitamin and mineral supplements for preventing age‐related macular degeneration 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Multivitamin vs placebo

• Antioxidant vitamin and mineral supplements for preventing age‐related macular degeneration 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate

Glass ionomer-based sealant vs Resin-based sealant

• Pit and fissure sealants for preventing dental decay in permanent teeth 2017 · Cochrane All outcomes
  One trial measured adverse effects. None reported.
  1 study
  GRADE not reported

Mannitol vs placebo / no treatment

The review found no eligible studies for this question.

• Volume expanders for the prevention of ovarian hyperstimulation syndrome 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Human albumin vs placebo or no treatment

The review found no eligible studies for this question.

• Volume expanders for the prevention of ovarian hyperstimulation syndrome 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

HES vs placebo or no treatment

The review found no eligible studies for this question.

• Volume expanders for the prevention of ovarian hyperstimulation syndrome 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NSAIDs vs steroids

• Prophylactic non‐steroidal anti‐inflammatory drugs for the prevention of macular oedema after cataract surgery 2016 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 488 participants
  GRADE not reported

NSAIDS plus steroids vs steroids

• Prophylactic non‐steroidal anti‐inflammatory drugs for the prevention of macular oedema after cataract surgery 2016 · Cochrane Headline outcomes only
  no estimate extracted
  18 studies · 18 participants
  GRADE not reported

Xylitol lozenges (4.7 g/day) vs no treatment

• Xylitol‐containing products for preventing dental caries in children and adults 2015 · Cochrane All outcomes

  24 months (48-month follow-up)
  There were no usable data presented for adverse effects. Lenkkeri 2012.
  1 study
  GRADE not reported

Fluoride toothpaste containing 10% xylitol vs Fluoride toothpaste alone

• Xylitol‐containing products for preventing dental caries in children and adults 2015 · Cochrane All outcomes

  2.5 to 3 years
  Adverse effects: both studies reported that there were no adverse effects in either the xylitol or control group.
  2 studies · 4216 participants
  GRADE not reported

Xylitol candy (7.5 g/day) vs Control (sorbitol) candy

• Xylitol‐containing products for preventing dental caries in children and adults 2015 · Cochrane All outcomes

  36 months
  The authors reported that there were no adverse effects for either group. Honkala 2014.
  1 study · 252 participants
  GRADE not reported

Acupoint PC6 stimulation and antiemetic combination vs antiemetics

• Stimulation of the wrist acupuncture point PC6 for preventing postoperative nausea and vomiting 2015 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 7 participants
  GRADE not reported

Acupoint PC6 stimulation vs sham

• Stimulation of the wrist acupuncture point PC6 for preventing postoperative nausea and vomiting 2015 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 35 participants
  GRADE not reported

Acupoint PC6 stimulation vs antiemetics

• Stimulation of the wrist acupuncture point PC6 for preventing postoperative nausea and vomiting 2015 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 11 participants
  GRADE not reported

Omega‐3 vs placebo

Omega 3 fatty acids leads to higher adverse effects compared with placebo (high certainty).

• Omega 3 fatty acids for preventing or slowing the progression of age‐related macular degeneration 2015 · Cochrane Headline outcomes only
  RR 1.01
  2 studies · 2343 participants
  High

Xylitol wipes (4.2 g/day) vs Control wipes (no xylitol)

• Xylitol‐containing products for preventing dental caries in children and adults 2015 · Cochrane All outcomes

  12 months
  The authors reported that there were no adverse effects for either group. Zhan 2012.
  1 study · 44 participants
  GRADE not reported

Resin composite restorations containing antibacterial agents vs Non-antibacterial containing composite restorations

The review found no eligible studies for this question.

• Antibacterial agents in composite restorations for the prevention of dental caries 2013 · Cochrane All outcomes
  No studies were included in this review, as we were unable to find any trials directly comparing antibacterial containing composites to other active interventions or controls.
  0 studies
  No studies found