What do systematic reviews say?

hCG vs placebo/no treatment

hCG may leads to higher OHSS compared with placebo/no treatment (low certainty).

• Luteal phase support for assisted reproduction cycles 2015 · Cochrane Headline outcomes only
  OR 4.28 [1.91, 9.6]
  1 study · 387 participants
  Low

hCG vs GnRH agonist

hCG showed no clear difference in OHSS per cycle compared with gnRH‐a (low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 2.27 [0.65, 7.91]
  3 studies · 456 participants
  Low

RhCG vs uhCG

RhCG showed no clear difference in OHSS per woman ‐ moderate to severe OHSS compared with uhCG (low certainty).

• Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles 2016 · Cochrane Headline outcomes only
  OR 1.76 [0.37, 8.45]
  3 studies · 417 participants
  Low

u‐hCG vs r‐hCG

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 468 participants
  Moderate

Low‐dose hCG vs FSH throughout the COH

It is very uncertain whether low‐dose hCG changes OHSS compared with FSH throughout the COH (very low certainty).

• FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive techniques 2013 · Cochrane Headline outcomes only
  OR 0.3 [0.06, 1.59]
  5 studies · 351 participants
  Very low