Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

780 questions · 834 findings · 76 reviews

No studies found 187 · 22.4%GRADE not reported 164 · 19.7%Very low 144 · 17.3%Low 172 · 20.6%Moderate 105 · 12.6%High 62 · 7.4%

Vitamin E + vitamin C vs placebo

Any adverse effects of vitamin supplementation sufficient to stop supplementation · pregnant women

Vitamin C and vitamin E showed no clear difference in any adverse effects of vitamin supplementation sufficient to stop… compared with placebo (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo or control

Maternal vitamin D concentration at term (25‐hydroxyvitamin D) (nmol/L) (ALL) · pregnant women

Meta-analysis of randomised trials of vitamin D supplementation for Maternal vitamin D concentrations at term: WMD 47.08 (95% CI 23.76 to 70.39), statistically significant. Umbrella review outcome-level evidence grade: Probable.

1 finding from 1 review

High-dose vitamin D3 supplementation during pregnancy (2400 IU/day from pregnancy week 24 to 1 week postpartum, in addition to the recommended 400 IU/day) vs Low-dose (standard) vitamin D supplementation as recommended in national pregnancy guidelines

Caries presence in primary teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

It is very uncertain whether high-dose vitamin D3 supplementation during pregnancy (2400 IU/day… changes caries presence in primary teeth compared with low-dose (standard) vitamin D supplementation as recommended in… (very low certainty).

1 finding from 1 review

High-dose vitamin D3 supplementation during pregnancy (2400 IU/day from pregnancy week 24 to 1 week postpartum, in addition to the recommended 400 IU/day) vs Low-dose (standard) vitamin D supplementation as recommended in national pregnancy guidelines

Dental caries · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

The review found no eligible studies for this question.

2 findings from 1 review

Vitamin D given to infants vs vitamin D given to lactating mothers

Hypercalcaemia · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to infants showed no clear difference in adverse effect (hypercalcaemia) compared with vitamin D given to lactating mothers (low certainty).

1 finding from 1 review