Findings

What do systematic reviews say?

780 questions · 834 findings · 76 reviews

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No studies found 187 · 22.4%GRADE not reported 164 · 19.7%Very low 144 · 17.3%Low 172 · 20.6%Moderate 105 · 12.6%High 62 · 7.4%

Vitamin K vs control

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin K vs control

PIVKA II levels: change in PIVKA II (ng/mL) · adults and children with cystic fibrosis

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Vitamin K vs control

Uncarboxylated osteocalcin: change in carboxylation of osteocalcin (% Glu‐OC) · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D vs placebo

Serum 25-hydroxyvitamin D level · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Moderate

Vitamin D vs placebo

Total body BMD measured by DEXA (% change from baseline) · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D vs placebo

Adverse events · people with sickle cell disease

Vitamin D showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 3.16 [0.14, 72.84]
1 study · 37 participants
Low

Vitamin D vs placebo

Pain frequency or change in pain frequency · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Low

Vitamin D vs placebo

Acute chest syndrome ( · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D vs placebo

Respiratory infections · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D vs placebo

HRQoL score (physical functioning) (change from baseline) · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Low

Vitamin D vs placebo or no intervention

Linear growth (length/height) Unit: cm Time frame: 3 months · children under 5 years of age

1 finding from 1 review

Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 240 participants
Low

Vitamin D vs placebo or no intervention

Mean height‐for‐age z‐score · children under 5 years of age

1 finding from 1 review

Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1258 participants
Moderate

Vitamin D vs placebo or no intervention

Stunting · children under 5 years of age

Vitamin D showed no clear difference in stunting Definition: L/HAZ < ‐2Time frame: 6 months compared with placebo or no intervention (moderate certainty).

1 finding from 1 review

Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
RR 0.9 [0.8, 1.01]
1 study · 1247 participants
Moderate

Vitamin D vs placebo or no intervention

Adverse effect: hypercalciuria As defined by trialists Time frame: 3 months · children under 5 years of age

Vitamin D showed no clear difference in adverse effect: hypercalciuria As defined by trialistsTime frame:… compared with placebo or no intervention (moderate certainty).

1 finding from 1 review

Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
RR 2.03 [0.28, 14.67]
2 studies · 68 participants
Moderate

Vitamin D vs placebo or no intervention

Hypercalcaemia · children under 5 years of age

It is very uncertain whether vitamin D changes adverse effect: hypercalcaemia As defined by trialistsTime frame:… compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
RR 0.82 [0.35, 1.9]
2 studies · 367 participants
Very low

Vitamin D vs placebo or no intervention

Adverse effect: hyperphosphataemiae · children under 5 years of age

The review found no eligible studies for this question.

1 finding from 1 review

Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D vs placebo or no intervention

Adverse effect: kidney stonesb · children under 5 years of age

The review found no eligible studies for this question.

1 finding from 1 review

Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin E vs placebo

Tardive dyskinesia: No clinically important improvement · patients with antipsychotic‐induced tardive dyskinesia

VITAMIN E showed no clear difference in tardive dyskinesia: 1. Not improved to a clinically important extent compared with PLACEBO (low certainty).

1 finding from 1 review

Vitamin E for antipsychotic‐induced tardive dyskinesia 2018 · Cochrane Headline outcomes only
RR 0.95 [0.89, 1.01]
6 studies · 264 participants
Low

Vitamin E vs placebo

Tardive dyskinesia: Deterioration of symptoms · patients with antipsychotic‐induced tardive dyskinesia

VITAMIN E may leads to lower tardive dyskinesia: 3. Deterioration of symptoms compared with PLACEBO (low certainty).

1 finding from 1 review

Vitamin E for antipsychotic‐induced tardive dyskinesia 2018 · Cochrane Headline outcomes only
RR 0.23 [0.07, 0.76]
5 studies · 85 participants
Low

Vitamin E vs placebo

Adverse effect: any · patients with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether VITAMIN E changes adverse effect: any compared with PLACEBO (very low certainty).

1 finding from 1 review

Vitamin E for antipsychotic‐induced tardive dyskinesia 2018 · Cochrane Headline outcomes only
RR 1.21 [0.35, 4.15]
9 studies · 205 participants
Very low