Cochrane · systematic review · CD008482
Vitamin K supplementation for cystic fibrosis
Jagannath, VA, Thaker, V, Chang, AB, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
3
No studies
11
Included studies
NR
No studies 11 · 78.6%Ungraded 0 · 0%Very low 3 · 21.4%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Vitamin K compared to control for people with cystic fibrosis
Population: people with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to cessation of bleeding Vitamin K vs control | no estimate extracted | NR | No studies |
Bone mineral density: lumbar spine z score Vitamin K vs control | no estimate extracted | 1 study · 38 participants | Very low Downgraded: risk of bias |
QoL: CFQ‐R Vitamin K vs control | no estimate extracted | NR | No studies |
QoL: CFQoL Vitamin K vs control | no estimate extracted | NR | No studies |
Adverse events Vitamin K vs control | no estimate extracted | NR | No studies |
PIVKA II levels: change in PIVKA II (ng/mL) Vitamin K vs control | no estimate extracted | 1 study · 18 participants | Very low Downgraded: risk of bias, imprecision |
Uncarboxylated osteocalcin: change in carboxylation of osteocalcin (% Glu‐OC) Vitamin K vs control | no estimate extracted | NR | No studies |
Comparison of different vitamin K doses for people with cystic fibrosis
Population: people with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to cessation of bleeding | no estimate extracted | NR | No studies |
Bone mineral density: lumbar spine z score | no estimate extracted | NR | No studies |
QoL: CFQ‐R | no estimate extracted | NR | No studies |
QoL: CFQoL | no estimate extracted | NR | No studies |
Adverse events | no estimate extracted | NR | No studies |
PIVKA II levels: change in PIVKA II (ng/mL) | no estimate extracted | NR | No studies |
Uncarboxylated osteocalcin: change in carboxylation of osteocalcin level (% Glu‐OC) | no estimate extracted | 1 study · 13 participants | Very low Downgraded: imprecision |