Vascular calcification · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Vascular calcification: RR 1.09 (95% CI 0.45 to 2.67), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
All‐cause mortality · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Mortality: RR 1.34 (95% CI 0.34 to 5.24), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Alkaline phosphatase · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Alkaline phosphatase: WMD -27.35 (95% CI -50.69 to -4.01), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Parathyroidectomy · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Parathyroidectomy: RR 0.82 (95% CI 0.05 to 12.47), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Alkaline phosphatase · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Alkaline phosphatase: WMD -21.81 (95% CI -40.39 to 3.22), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Risk of hyperphosphataemia · Adults with chronic kidney disease not requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Risk of hyperphosphataemia: RR 1.58 (95% CI 0.47 to 5.30), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Bone pain · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Bone pain: RR 0.29 (95% CI 0.03 to 2.63), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Maternal vitamin B12 deficiency · pregnant women
It is very uncertain whether summary of findings table ‐ Vitamin B12 supplementation changes maternal vitamin B12 deficiency compared with placebo/no vitamin B12 supplementation (very low certainty).
1 finding from 1 review
Vitamin A deficiency · mortality and morbidity in term neonates
Neonatal vitamin A supplementation showed no clear difference in vitamin A deficiency (serum retinol < 0.70 micromol/L) at 6 weeks of… compared with control (high certainty).
2 findings from 1 review
Caries presence in primary teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
It is very uncertain whether high-dose vitamin D3 supplementation during pregnancy (2400 IU/day… changes caries presence in primary teeth compared with low-dose (standard) vitamin D supplementation as recommended in… (very low certainty).
1 finding from 1 review
Dental caries · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
The review found no eligible studies for this question.
2 findings from 1 review
Stillbirth · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…
Any vitamin E supplementation showed no clear difference in stillbirth compared with placebo, no placebo or other supplements (moderate certainty).
1 finding from 1 review
Preterm birth · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…
Any vitamin E supplementation showed no clear difference in preterm birth (less than 37 weeks' gestation) compared with placebo, no placebo or other supplements (high certainty).
1 finding from 1 review
Pre‐eclampsia · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…
Any vitamin E supplementation showed no clear difference in clinical pre‐eclampsia (random‐effects model) compared with placebo, no placebo or other supplements (moderate certainty).
1 finding from 1 review
Intrauterine growth restriction · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…
Any vitamin E supplementation showed no clear difference in intrauterine growth restriction (various definitions) compared with placebo, no placebo or other supplements (high certainty).
1 finding from 1 review
Preterm prelabour rupture of membranes · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…
Any vitamin E supplementation showed no clear difference in prelabour rupture of fetal membranes ‐ preterm compared with placebo, no placebo or other supplements (low certainty).
1 finding from 1 review
Bleeding episodes (placental abruption) · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…
Any vitamin E supplementation leads to lower bleeding episodes (placental abruption) compared with placebo, no placebo or other supplements (high certainty).
1 finding from 1 review
All‐cause mortality · children aged between 6 months and 5 years
Vitamin A supplementation leads to lower all‐cause mortality compared with placebo or usual care (high certainty).
1 finding from 1 review
Vomiting · children aged between 6 months and 5 years
Vitamin A supplementation probably leads to higher vomiting compared with placebo or usual care (moderate certainty).
1 finding from 1 review
Mortality due to diarrhoea · children aged between 6 months and 5 years
Vitamin A supplementation leads to lower mortality due to diarrhoea compared with placebo or usual care (high certainty).
1 finding from 1 review