Caries lesion arrestment · Primary teeth with dentin caries lesions on occlusal and smooth surfaces
Silver diamine fluoride twice annually ranked first for caries lesion arrestment in the occlusal- and smooth-surface network (moderate certainty).
1 finding from 1 review
new root-surface carious lesions or restorations · community-dwelling older adults with root caries
SDF had a 28% preventative fraction at 24 months; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
Caries arrest · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars
Biannual SDF application significantly arrested caries (pooled ES 0.39, 95% CI 0.19-0.60; ungraded).
1 finding from 1 review
Caries arrest · Children with dentine carious lesions (ICDAS 4-5) in primary teeth
Twice-yearly 38% SDF was reported to arrest more caries than once-yearly application (24-month rates 91% vs 79%; ungraded).
1 finding from 1 review
Secondary prevention of caries · children with deep occlusal carious lesions in permanent molars
No significant difference in secondary caries prevention was reported; no effect estimate or GRADE rating was reported.
1 finding from 1 review
Immediate bond strength (MPa) · Glass-ionomer cement bonded to sound dentin (in vitro)
SDF pretreatment with a rinsing step does not affect glass-ionomer cement bond strength to sound dentin (MD -1.11 MPa, 95% CI -3.47 to 1.25; ungraded).
1 finding from 1 review
Immediate bond strength (MPa) · Glass-ionomer cement bonded to caries-affected dentin (in vitro)
SDF pretreatment with a rinsing step does not affect glass-ionomer cement bond strength to caries-affected dentin (MD -0.36 MPa, 95% CI -1.07 to 0.35; ungraded).
1 finding from 1 review
Immediate bond strength (MPa) · Dental adhesives bonded to sound dentin (in vitro)
A rinsing step after SDF eliminates the negative effect on adhesive bond strength to sound dentin (MD 7.11 MPa, 95% CI -0.57 to 14.79, non-significant; ungraded).
1 finding from 1 review
Caries arrest · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars
SDF was not significantly better than ART at arresting caries (pooled ES 0.05, 95% CI -0.42 to 0.51; ungraded).
1 finding from 1 review
Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro)
Prior SDF followed by a rinsing step significantly increases adhesive bond strength to caries-affected dentin (MD -4.79 MPa favoring SDF, 95% CI -9.19 to -0.40; ungraded).
1 finding from 1 review
Arrest of dentine caries · Preschool children with active dentine caries in primary teeth (mean age 3.4-4.0 years)
Silver diamine fluoride was about 2.5 times more likely than sodium fluoride to arrest dentine caries surfaces at 18 months (pooled OR 2.51, 95% CI 1.25 to 5.10; 2 RCTs), although between-study heterogeneity was high (I2=90.3%); certainty of evidence was not formally graded.
2 findings from 1 review
Arrest of advanced cavitated carious lesions on any coronal surface · Preschool children with advanced cavitated carious lesions on any coronal surface (primary teeth)
30% SDF solution (once weekly for 3 weeks) probably did not differ from 5% NaF varnish (once weekly for 3 weeks) for arrest or reversal of cavitated coronal carious lesions (RR 0.97, 95% CI 0.8 to 1.18; moderate certainty).
3 findings from 1 review
new root-surface carious lesions or restorations · Older adults with root caries in permanent (mature) teeth (mean age 75 years)
SDF had a 71% preventative fraction at 36 months; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
Immediate bond strength (MPa) · Glass-ionomer cement bonded to caries-affected dentin (in vitro)
SDF pretreatment without a rinsing step does not affect glass-ionomer cement bond strength to caries-affected dentin (MD 0.26 MPa, 95% CI -0.30 to 0.82; ungraded).
1 finding from 1 review
Immediate bond strength (MPa) · Dental adhesives bonded to sound dentin (in vitro)
Prior SDF without a rinsing step significantly reduces adhesive bond strength to sound dentin (MD 17.52 MPa favoring untreated dentin, 95% CI 5.81 to 29.22; ungraded).
1 finding from 1 review
Immediate bond strength (MPa) · Glass-ionomer cement bonded to sound dentin (in vitro)
SDF pretreatment without a rinsing step does not affect glass-ionomer cement bond strength to sound dentin (MD 0.26 MPa, 95% CI -0.20 to 0.73; ungraded).
1 finding from 1 review
Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro)
Only one study assessed SDF without a rinsing step on adhesive bonding to caries-affected dentin (Kucukyilmaz 2016, which reported impaired bond strength); no meta-analysis was possible, so no pooled estimate is available.
1 finding from 1 review
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
Only one in vitro study assessed a Self-Etch adhesive with the biological ACAD protocol; it was insufficient for network meta-analysis, so no pooled effect estimate is available (ungraded).
1 finding from 1 review
Prevention of new caries (caries development/increment) · Preschool children (primary dentition) at risk of new caries
Limited evidence from two trials suggests SDF may help prevent new caries, but preventive efficacy was not meta-analyzed and remains uncertain (ungraded).
1 finding from 1 review
Caries arrest · Children and adults (with or without carious lesions)
Silver diamine fluoride (SDF) plus fluoride varnish showed no clear difference in caries arrest compared with sealants plus fluoride varnish (with or without restorations) (low certainty).
1 finding from 1 review