Secondary prevention of caries · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Primary caries prevention · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects (tooth staining and other side effects) · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
SDF commonly causes black staining of arrested lesions; only mild, transient adverse events were reported, with no major adverse events (ungraded).
1 finding from 1 review
Secondary prevention of caries · children with deep occlusal carious lesions in permanent molars
No significant difference in secondary caries prevention was reported; no effect estimate or GRADE rating was reported.
1 finding from 1 review
Caries arrest · Children and adults (with or without carious lesions)
1 finding from 1 review
In 1 study (45 children), 4 applications of 38% SDF at 1-monthly intervals resulted in fewer surfaces with active caries compared with 2 applications at 6-monthly intervals (MD 1.04 surfaces, 95% CI 0.23 to 1.85), and…
4 studies · 1360 participants
Very low
Secondary prevention of caries · Children and adults (with or without carious lesions)
It is very uncertain whether SDF (given at a particular frequency, concentration, or duration) changes secondary prevention of caries compared with SDF (given at a different frequency, concentration, or duration) (very low certainty).
1 finding from 1 review
Primary caries prevention · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Dental pain or sensitivity · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
new active or inactive carious lesions · Children with dental caries in permanent (first) molars
SDF had a 72% preventative fraction; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
new carious lesions or fillings at tooth level · children with caries in permanent molars
SDF had a 41% preventative fraction at tooth level; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
new carious lesions or fillings · Children with dental caries in permanent (first) molars
SDF had a 57% preventative fraction; the comparator was not reported.
1 finding from 1 review
new carious lesions or fillings at fissure-site level · children with caries in permanent molars
SDF had a 52% preventative fraction at fissure-site level; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
Oral health-related quality of life · Children with dental caries
SDF had no significant effect on oral health-related quality of life versus pooled standard-of-care caries treatments (SMD -0.06, 95% CI -0.20 to 0.08; ungraded).
1 finding from 1 review
Restoration color, marginal staining and luster (esthetics) · Children with deep occlusal caries in young permanent first molars (indirect pulp capping)
RMGIC gave significantly better restoration esthetics than SDF, which caused black staining (p=0.03; ungraded).
1 finding from 1 review
Baraka et al. (2022): significant differences in restoration color, marginal staining and luster favoring RMGIC over both SDF groups (p=0.03); SDF caused black staining that darkened over time.
1 study · 49 participants
GRADE not reported
new root-surface carious lesions or restorations · community-dwelling older adults with root caries
SDF plus oral health education had a 33% preventative fraction at 24 months; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
new root-surface carious lesions or restorations · community-dwelling older adults with root caries
SDF had a 62% preventative fraction; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
Oral health-related quality of life · Children with dental caries
SDF did not significantly differ from placebo for oral health-related quality of life in children (MD 0.03, 95% CI -0.16 to 0.22; ungraded).
1 finding from 1 review
Oral health-related quality of life · Children with dental caries
SDF did not significantly differ from atraumatic restorative treatment for oral health-related quality of life (MD 0.02, 95% CI -0.32 to 0.36; ungraded).
1 finding from 1 review
new root-surface carious lesions or restorations · community-dwelling older adults with root caries
SDF had a 28% preventative fraction at 24 months; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
new root-surface carious lesions or restorations · Older adults with root caries in permanent (mature) teeth (mean age 75 years)
SDF had a 71% preventative fraction at 36 months; no pooled estimate or GRADE rating was reported.
1 finding from 1 review