Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

28 questions · 28 findings · 2 reviews · Headline outcomes only

No studies found 4 · 14.3%GRADE not reported 1 · 3.6%Very low 9 · 32.1%Low 14 · 50%Moderate 0 · 0%High 0 · 0%

SSRIs or SNRIs vs amitriptyline

Participants who withdraw because of an adverse event or any other reason · patients for whom migraine preventive interventions are indicated

SSRIs or SNRIs showed no clear difference in withdrawn (for any reasons and due to adverse events) compared with amitriptyline (low certainty).

1 finding from 1 review