Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

22 questions · 23 findings · 6 reviews · Schizophrenia

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 10 · 43.5%Low 7 · 30.4%Moderate 6 · 26.1%High 0 · 0%

RISPERIDONE vs OLANZAPINE

Leaving the study early · people with both severe mental illness and substance misuse

It is very uncertain whether RISPERIDONE changes leaving study early: any reason compared with OLANZAPINE ‒ short‐ and long‐term data (very low certainty).

1 finding from 1 review

RISPERIDONE vs QUETIAPINE

Leaving the study early · people with both severe mental illness and substance misuse

RISPERIDONE showed no clear difference in leaving the study early: 1. any reason, long term (>12 months) compared with QUETIAPINE ‒ short‐ and long‐term data (low certainty).

1 finding from 1 review

RISPERIDONE vs ZIPRASIDONE ‒ long‐term data (> 12 months)

Leaving the study early · people with both severe mental illness and substance misuse

RISPERIDONE showed no clear difference in leaving the study early: any reason compared with ZIPRASIDONE ‒ long‐term data (> 12 months) (low certainty).

1 finding from 1 review

RISPERIDONE vs CLOZAPINE ‐ all data short term

Leaving the study early · people with both severe mental illness and substance misuse

It is very uncertain whether RISPERIDONE changes leaving the study early ‒ any reason compared with CLOZAPINE ‐ all data short term (very low certainty).

1 finding from 1 review

RISPERIDONE vs placebo

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

RISPERIDONE may leads to lower leaving the study early ‐ short term (up to 12 weeks) ‐ any reason compared with PLACEBO (low certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs RISPERIDONE

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

RISPERIDONE DEPOT showed no clear difference in leaving the study early: Any reason ‐ short term compared with ORAL RISPERIDONE (moderate certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs QUETIAPINE

Leaving the study early · patients with schizophrenia

RISPERIDONE DEPOT probably leads to lower leaving the study early: Any reason ‐ long term compared with ORAL QUETIAPINE (moderate certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs ARIPIPRAZOLE

Leaving the study early · patients with schizophrenia

It is very uncertain whether RISPERIDONE DEPOT changes leaving the study early: Any reason ‐ long term compared with ORAL ARIPIPRAZOLE (very low certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs placebo

Leaving the study early · patients with schizophrenia

It is very uncertain whether RISPERIDONE DEPOT changes leaving the study early: Any reason ‐ all doses risperidone depot ‐… compared with PLACEBO (very low certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs OLANZAPINE

Leaving the study early · patients with schizophrenia

RISPERIDONE DEPOT may leads to higher leaving the study early: Any reason ‐ long term compared with ORAL OLANZAPINE (low certainty).

1 finding from 1 review

CLOZAPINE + RISPERIDONE vs CLOZAPINE + ZIPRASIDONE (Kuwilsky 2010)

Acceptability of treatment ‐ leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + RISPERIDONE changes leaving the study early: acceptability of treatment ‐ as measured by… compared with CLOZAPINE + ZIPRASIDONE (Kuwilsky 2010) (very low certainty).

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy + risperidone vs placebo and cognitive and behavioural therapies

Satisfaction with treatment: leaving the study early Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes satisfaction with treatment: leaving the study early Endpoint data… compared with cognitive behavioural therapy + placebo (very low certainty).

1 finding from 1 review

Group C cognitive behavioural therapy: cognitive behavioural therapy + risperidone vs placebo or supportive treatment

Satisfaction with treatment: leaving the study early Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group C cognitive behavioural therapy: cognitive behavioural therapy… changes satisfaction with treatment: leaving the study early Endpoint data… compared with supportive therapy + placebo (very low certainty).

1 finding from 1 review