'Substantial benefit' (≥ 50% reduction in pain or PGIC very much improved) · adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)
1 finding from 1 review
Withdrawals due to adverse events · adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)
1 finding from 1 review
Lack of efficacy withdrawal · adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)
1 finding from 1 review
Serious adverse events · adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)
1 finding from 1 review
Death · adults with neuropathic pain (2 studies in peripheral diabetic neuropathy and 1 study in postherpetic neuralgia)
1 finding from 1 review
Pain intensity (mean across treatment or at end of treatment; length of treatment varied across trials; various pain intensity scales; SMD) · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes pain intensity (mean across treatment or at end of treatment; length… compared with IR oxycodone (very low certainty).
1 finding from 1 review
Constipation · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes constipation (Event rate during treatment, length of treatment… compared with IR oxycodone (very low certainty).
1 finding from 1 review
Drowsiness/somnolence (Event rate during treatment, length of treatment varied across trials) · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes drowsiness/somnolence (Event rate during treatment, length of… compared with IR oxycodone (very low certainty).
1 finding from 1 review
Nausea · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes nausea (Event rate during treatment, length of treatment varied… compared with IR oxycodone (very low certainty).
1 finding from 1 review
Vomiting · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes vomiting (Event rate during treatment, length of treatment varied… compared with IR oxycodone (very low certainty).
1 finding from 1 review
Quality of life · adults with cancer‐related pain
1 finding from 1 review
Participant preference · adults with cancer‐related pain
The review found no eligible studies for this question.
1 finding from 1 review
Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Substantial benefit: At least 50% reduction in pain, or PGIC much improved · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Lack of efficacy withdrawal · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Withdrawals due to adverse events · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Serious adverse events · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Deaths · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Constipation · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes constipation ‐ only English language studies (Event rate during… compared with CR morphine (very low certainty).
2 findings from 1 review