All adverse effects ‐ ibuprofen versus paracetamol · women with primary dysmenorrhoea
It is very uncertain whether NSAIDs changes all adverse effects ‐ ibuprofen versus paracetamol compared with paracetamol (very low certainty).
1 finding from 1 review
OR 0.85 [0.31, 2.34]
Studies not reported
Very low
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) probably leads to lower pain intensity (VAS 0-100 mm) compared with control (placebo or no treatment) (moderate certainty).
3 findings from 1 review
MD -11.66 [-16.15, -7.17]
10 studies · 685 participants
Moderate
MD -21.19 [-28.31, -14.06]
12 studies · 1012 participants
Moderate
MD -24.27 [-31.44, -17.11]
9 studies · 535 participants
Moderate
Quality of life or participant satisfaction · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
1 finding from 1 review
Rescue analgesia · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
1 finding from 1 review
Time off school or work · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
Failure to complete orthodontic treatment due to pain · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
hours
It is very uncertain whether NSAIDs changes hours compared with paracetamol (very low certainty).
1 finding from 1 review
to 72 hours
NSAIDs showed no clear difference in to 72 hours compared with paracetamol (low certainty).
1 finding from 1 review
to 7 days
It is very uncertain whether NSAIDs changes to 7 days compared with paracetamol (very low certainty).
1 finding from 1 review
Adverse events
It is very uncertain whether NSAIDs changes adverse events compared with paracetamol (very low certainty).
1 finding from 1 review
Mean time to resolution of pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Reconsultations
It is very uncertain whether NSAIDs changes reconsultations compared with paracetamol (very low certainty).
1 finding from 1 review
Delayed antibiotic prescriptions
It is very uncertain whether NSAIDs changes delayed antibiotic prescriptions compared with paracetamol (very low certainty).
1 finding from 1 review
Reduction in pain intensity · people with acute soft tissue injury, such as ankle sprain
1 finding from 1 review
Little or no pain at < 24 hours · people with acute soft tissue injury, such as ankle sprain
1 finding from 1 review
Little or no pain at 1 to 3 days · people with acute soft tissue injury, such as ankle sprain
It is very uncertain whether NSAID changes little or no pain at 1 to 3 days compared with combination (paracetamol and opioid) analgesic (very low certainty).
2 findings from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · people with acute soft tissue injury, such as ankle sprain
1 finding from 1 review
Swelling (7th day) · people with acute soft tissue injury, such as ankle sprain
1 finding from 1 review
Return to function on day 7 or later Assessed as 'cure' · people with acute soft tissue injury, such as ankle sprain
It is very uncertain whether NSAID changes return to function on day 7 or later Assessed as 'cure' compared with combination (paracetamol and opioid) analgesic (very low certainty).
1 finding from 1 review