What do systematic reviews say?

NSAIDs vs paracetamol

It is very uncertain whether NSAIDs changes hours compared with paracetamol (very low certainty).

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  RR 0.83 [0.59, 1.18]
  2 studies · 39 participants
  Very low

NSAIDs vs paracetamol

NSAIDs showed no clear difference in to 72 hours compared with paracetamol (low certainty).

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  RR 0.91 [0.54, 1.54]
  3 studies · 183 participants
  Low

NSAIDs vs placebo

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

NSAIDs vs combination (paracetamol and opioid) analgesic

• Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 51 participants
  Very low

NSAIDs vs paracetamol

• Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 1178 participants
  High

NSAIDs vs placebo

NSAIDs may leads to lower to 72 hours (48 hours) compared with placebo (low certainty).

• Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
  RR 0.28 [0.11, 0.7]
  1 study · 146 participants
  Low

NSAID (single administration, any dose) vs paracetamol

NSAID (single administration, any dose) may leads to higher adequate pain relief (4 hours after administration) compared with paracetamol (low certainty).

• Oral non‐steroidal anti‐inflammatory drugs (single dose) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
  RR 1.54 [1.07, 2.22]
  3 studies · 342 participants
  Low
• Oral non‐steroidal anti‐inflammatory drugs (single dose) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
  RR 1.82 [0.61, 5.47]
  2 studies · 99 participants
  Very low

NSAID (single administration, any dose) vs paracetamol

It is very uncertain whether NSAID (single administration, any dose) changes need for additional analgesia (4 hours after administration) compared with paracetamol (very low certainty).

• Oral non‐steroidal anti‐inflammatory drugs (single dose) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
  RR 0.55 [0.27, 1.13]
  1 study · 73 participants
  Very low

NSAID (single administration, any dose) vs paracetamol

NSAID (single administration, any dose) may leads to lower need for additional analgesia (6 hours after administration) compared with paracetamol (low certainty).

• Oral non‐steroidal anti‐inflammatory drugs (single dose) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
  RR 0.28 [0.12, 0.67]
  1 study · 59 participants
  Low

NSAID (single administration, any dose) vs paracetamol

• Oral non‐steroidal anti‐inflammatory drugs (single dose) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 210 participants
  GRADE not reported

NSAID (single administration, any dose) vs paracetamol

It is very uncertain whether NSAID (single administration, any dose) changes maternal drug adverse effects (6 hours after administration) compared with paracetamol (very low certainty).

• Oral non‐steroidal anti‐inflammatory drugs (single dose) for perineal pain in the early postpartum period 2021 · Cochrane Headline outcomes only
  RR 0.74 [0.27, 2.08]
  3 studies · 300 participants
  Very low