Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

82 questions · 86 findings · 11 reviews · Heart

No studies found 13 · 15.1%GRADE not reported 0 · 0%Very low 12 · 14%Low 37 · 43%Moderate 17 · 19.8%High 7 · 8.1%

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Myocardial infarction · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in myocardial infarction compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Stroke · people with or without existing cardiovascular disease, men and women

It is very uncertain whether homocysteine‐lowering interventions (high dose) changes stroke compared with homocysteine‐lowering interventions (low dose) (very low certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in death by any cause compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Face‐to‐face interventions vs control

Physical activity · patients with promoting physical activity

Face‐to‐face interventions showed no clear difference in dichotomous outcomes: 12 months Self‐reported PA questionnaire compared with control (high certainty).

4 findings from 1 review
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