Findings

What do systematic reviews say?

63 questions · 64 findings · 11 reviews

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No studies found 2 · 3.1%GRADE not reported 4 · 6.3%Very low 12 · 18.8%Low 29 · 45.3%Moderate 17 · 26.6%High 0 · 0%

Inhaled corticosteroids vs placebo

Lung function (spirometry indices) ‐ FVC (in L, end study minus baseline values) · people with bronchiectasis

1 finding from 1 review

Inhaled corticosteroids for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 156 participants
Low

Inhaled corticosteroids vs placebo

Lung function (other indices) ‐ diffusion capacity % predicted (end of study) · people with bronchiectasis

1 finding from 1 review

Inhaled corticosteroids for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 57 participants
Low

Inhaled corticosteroids vs placebo

Lung function (other indices) ‐ RV % predicted (end of study values) · people with bronchiectasis

1 finding from 1 review

Inhaled corticosteroids for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 57 participants
Low

Inhaled corticosteroids vs placebo

Lung function (other indices) ‐ TLC % predicted (end of study values) · people with bronchiectasis

1 finding from 1 review

Inhaled corticosteroids for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 57 participants
Low

Inhaled corticosteroids vs placebo

Exacerbations · people with bronchiectasis

1 finding from 1 review

Inhaled corticosteroids for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 127 participants
Low

Inhaled corticosteroids vs placebo

Pseudomonas aeruginosa (P aeruginosa) colonisation · people with bronchiectasis

Inhaled corticosteroids showed no clear difference in pseudomonas aeruginosa (P aeruginosa) colonisation compared with placebo (low certainty).

1 finding from 1 review

Inhaled corticosteroids for bronchiectasis 2018 · Cochrane Headline outcomes only
OR 0.94 [0.45, 1.96]
2 studies · 156 participants
Low

Inhaled corticosteroids vs placebo

FEV1 % predicted: absolute change from baseline · people with bronchiectasis

1 finding from 1 review

Inhaled corticosteroids for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 86 participants
Low

Inhaled corticosteroids vs placebo

FVC (% predicted) Change from baseline · people with bronchiectasis

1 finding from 1 review

Inhaled corticosteroids for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 86 participants
Low

Inhaled corticosteroids vs placebo

Primary outcome · adults with subacute and chronic cough

The review found no eligible studies for this question.

1 finding from 1 review

Inhaled corticosteroids for subacute and chronic cough in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhaled corticosteroids vs placebo

Proportion of participants who achieved clinical cure or significant improvement (> 70% reduction in cough severity measure) at · adults with subacute and chronic cough

1 finding from 1 review

Inhaled corticosteroids for subacute and chronic cough in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 180 participants
Low

Inhaled corticosteroids vs placebo

Secondary outcomes · adults with subacute and chronic cough

The review found no eligible studies for this question.

1 finding from 1 review

Inhaled corticosteroids for subacute and chronic cough in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhaled corticosteroids vs placebo

Proportion of participants who achieved clinical cure or > 50% reduction in cough severity measure at · adults with subacute and chronic cough

1 finding from 1 review

Inhaled corticosteroids for subacute and chronic cough in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 230 participants
Low

Inhaled corticosteroids vs placebo

Clinical cure · adults with subacute and chronic cough

1 finding from 1 review

Inhaled corticosteroids for subacute and chronic cough in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 320 participants
Low

Inhaled corticosteroids vs placebo

Severity of cough (mean improvement score) · adults with subacute and chronic cough

Inhaled corticosteroids (ICS) showed no clear difference in mean change in cough score Symptomatic cough severity measure as… compared with placebo (low certainty).

1 finding from 1 review

Inhaled corticosteroids for subacute and chronic cough in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 346 participants
Low

Inhaled corticosteroids vs placebo

Proportion with adverse effects of treatment · adults with subacute and chronic cough

Inhaled corticosteroids (ICS) showed no clear difference in proportion with adverse effects of treatment compared with placebo (moderate certainty).

1 finding from 1 review

Inhaled corticosteroids for subacute and chronic cough in adults 2013 · Cochrane Headline outcomes only
OR 1.67 [0.92, 3.04]
4 studies · 381 participants
Moderate

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Oxygen requirement at 36 weeks' postmenstrual age · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) showed no clear difference in CLD at 36 weeks' PMA oxygen dependency at 36 weeks' PMA compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early administration of inhaled corticosteroids for preventing chronic lung disease in very low birth weight preterm… 2017 · Cochrane Headline outcomes only
RR 0.97 [0.62, 1.52]
5 studies · 429 participants
Moderate

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36 weeks' PMA · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) probably leads to lower death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36… compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early administration of inhaled corticosteroids for preventing chronic lung disease in very low birth weight preterm… 2017 · Cochrane Headline outcomes only
RR 0.86 [0.75, 0.99]
6 studies · 1285 participants
Moderate

Inhaled corticosteroids vs no treatment or placebo

Need for nasal continuous positive airway pressure · patients with the management of transient tachypnea of the newborn

It is very uncertain whether inhaled corticosteroids changes need for nasal continuous positive airway pressure compared with no treatment or placebo (very low certainty).

1 finding from 1 review

Postnatal corticosteroids for transient tachypnoea of the newborn 2020 · Cochrane Headline outcomes only
RR 1.27 [0.65, 2.51]
1 study · 49 participants
Very low

Inhaled corticosteroids vs no treatment or placebo

Need for mechanical ventilation · patients with the management of transient tachypnea of the newborn

It is very uncertain whether inhaled corticosteroids changes need for mechanical ventilation compared with no treatment or placebo (very low certainty).

1 finding from 1 review

Postnatal corticosteroids for transient tachypnoea of the newborn 2020 · Cochrane Headline outcomes only
RR 0.52 [0.05, 5.38]
1 study · 49 participants
Very low

Inhaled corticosteroids vs no treatment or placebo

Length of hospital stay · patients with the management of transient tachypnea of the newborn

1 finding from 1 review

Postnatal corticosteroids for transient tachypnoea of the newborn 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 49 participants
Very low