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Evidence found and GRADE certainty

26 questions · 36 findings · 2 reviews · Pain, Palliative and Supportive Care

No studies found 18 · 50%GRADE not reported 0 · 0%Very low 9 · 25%Low 5 · 13.9%Moderate 4 · 11.1%High 0 · 0%

Ibuprofen vs paracetamol

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

The review found no eligible studies for this question.

1 finding from 1 review

Ibuprofen vs morphine

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · children with acute postoperative pain

The review found no eligible studies for this question.

2 findings from 1 review

Ibuprofen vs morphine

Adverse events (reported in the first 7 days after the procedure) · children with acute postoperative pain

Ibuprofen probably leads to lower adverse events (reported in the first 7 days after the procedure) compared with morphine (moderate certainty).

1 finding from 1 review

Ibuprofen vs morphine

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

The review found no eligible studies for this question.

1 finding from 1 review

Ibuprofen vs ketorolac

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · children with acute postoperative pain

The review found no eligible studies for this question.

2 findings from 1 review

Ibuprofen vs ketorolac

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

The review found no eligible studies for this question.

1 finding from 1 review

Ibuprofen vs placebo

Adverse events (reported in the first 7 days after the procedure) · children with acute postoperative pain

Ibuprofen showed no clear difference in adverse events (reported in the first 7 days after the procedure) compared with placebo (low certainty).

1 finding from 1 review

Ibuprofen vs placebo

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

The review found no eligible studies for this question.

1 finding from 1 review

Ibuprofen vs placebo

At least 50% reduction in pain · health problem or population

It is very uncertain whether summary of Findings Table ‐ Ibuprofen changes number of participants with at least 50% pain relief at 4 hours compared with placebo (very low certainty).

2 findings from 1 review