Ibuprofen vs placebo: Adverse events (reported in the first 7 days after the procedure)
- Population
- children with acute postoperative pain
- Intervention
- Ibuprofen
- Comparison
- placebo
- Outcome
- Adverse events (reported in the first 7 days after the procedure)
Ibuprofen showed no clear difference in adverse events (reported in the first 7 days after the procedure) compared with placebo (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Ibuprofen vs placebo Adverse events (reported in the first 7 days after the procedure) · children aged 17 years or younger treated for acute postoperative or postprocedural pain Ibuprofen showed no clear difference in adverse events (reported in the first 7 days after the procedure) compared with placebo (low certainty). Ibuprofen for acute postoperative pain in children (2024) · Cochrane Headline outcomes only | RR 0.79 [0.51, 1.23] | 5 studies · 384 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Ibuprofen for acute postoperative pain in children 2024 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Ibuprofen vs ketorolac · children with acute postoperative pain · 1 review
- Ibuprofen vs paracetamol · children with acute postoperative pain · 1 review
- Ibuprofen vs morphine · children with acute postoperative pain · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.