Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

240 questions · 263 findings · 36 reviews

No studies found 18 · 6.8%GRADE not reported 92 · 35%Very low 68 · 25.9%Low 59 · 22.4%Moderate 21 · 8%High 5 · 1.9%

Late (seven days or more following birth) higher vs lower sodium intake

Mortality Mortality at latest · preterm or low birth weight infants

It is very uncertain whether late (seven days or more following birth) higher changes mortality (latest time reported up to hospital discharge) compared with lower sodium intake (very low certainty).

1 finding from 1 review

Higher‐dose vs lower‐dose nicotine patch

Smoking cessation · people who smoke

Higher‐dose showed no clear difference in smoking cessation ‐ 42/44 mg versus 21/22 mg (24‐hour patches) compared with lower‐dose nicotine patch (moderate certainty).

3 findings from 1 review

Higher‐dose vs lower‐dose nicotine patch

SAEs · people who smoke

Higher‐dose showed no clear difference in overall SAEs ‐ 42/44 mg versus 21/22 mg (24 hr patches) compared with lower‐dose nicotine patch (low certainty).

2 findings from 1 review

Higher‐dose vs lower‐dose nicotine patch

Treatment withdrawals ‐ 21 mg versus 14 mg (24‐hour patches) · people who smoke

Higher‐dose showed no clear difference in treatment withdrawals ‐ 21 mg versus 14 mg (24‐hour patches) compared with lower‐dose nicotine patch (low certainty).

1 finding from 1 review

Higher‐dose vs lower dose

Intermediate syndrome · patients with acute organophosphate pesticide poisoning

It is very uncertain whether higher dose changes intermediate syndrome compared with lower dose (very low certainty).

1 finding from 1 review