Findings

What do systematic reviews say?

20 questions · 20 findings · 17 reviews

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No studies found 10 · 50%GRADE not reported 5 · 25%Very low 4 · 20%Low 0 · 0%Moderate 1 · 5%High 0 · 0%

High vs low blood pressure target

Quality of life · adults undergoing cardiac surgery with cardiopulmonary bypass

It is very uncertain whether high changes quality of life compared with low blood pressure target (very low certainty).

1 finding from 1 review

High versus low blood pressure targets for cardiac surgery while on cardiopulmonary bypass 2022 · Cochrane Headline outcomes only
RR 0.78 [0.3, 2.01]
1 study · 218 participants
Very low

Higher vs lower FiO2 or targets of arterial oxygenation

Quality of life (any measure): range 180 d to 1 y · adults admitted to the ICU

1 finding from 1 review

Higher versus lower fractions of inspired oxygen or targets of arterial oxygenation for adults admitted to the… 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1649 participants
Very low

High‐dose vs low‐dose rFVIIa

Quality of life · adults and children with hemophilia A or B with inhibitors

The review found no eligible studies for this question.

1 finding from 1 review

Bypassing agent prophylaxis in people with hemophilia A or B with inhibitors 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

ASA + high‐dose LMWH vs ASA + low‐dose LMWH or UFH

Quality of life · people with antiphospholipid antibodies and no history of thrombosis

The review found no eligible studies for this question.

1 finding from 1 review

Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High‐dose vs low‐dose coenzyme Q10 and vitamin E

Longer‐term (minimum 1 month) change in generic quality of life scores · people with speech disorder resulting from hereditary ataxias

1 finding from 1 review

Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Quality of life · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High‐dose vs low‐dose coenzyme Q10 and vitamin E

Short‐term (within 1 month) change in quality of life scores related to communication as measured by validated communication assessments · people with speech disorder resulting from hereditary ataxias

1 finding from 1 review

Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

High‐pressure garment therapy vs low‐pressure garment therapy

Quality of life · people with burn wounds likely to develop hypertrophic scarring

The review found no eligible studies for this question.

1 finding from 1 review

Pressure‐garment therapy for preventing hypertrophic scarring after burn injury 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Other types of high tibial osteotomy (aHTO) vs closing wedge high tibial osteotomy (CW‐HTO)

Health‐related quality of life measures · patients with osteoarthritis of the knee

The review found no eligible studies for this question.

1 finding from 1 review

Osteotomy for treating knee osteoarthritis 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High‐intensity vs moderate‐intensity exercise

Health‐related quality of life · heart transplant recipients

1 finding from 1 review

Exercise‐based cardiac rehabilitation in heart transplant recipients 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Moderate

High dose 5‐ASA vs low dose 5‐ASA

Health related quality of life · people with surgically‐induced remission in Crohn's disease

The review found no eligible studies for this question.

1 finding from 1 review

Oral 5‐aminosalicylic acid for maintenance of surgically‐induced remission in Crohn's disease 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High‐treatment‐dose vitamin D (greater than 1000 IU/day) vs low‐treatment‐dose vitamin D (400 IU/day to 1000 IU/day)

Quality of life · people with inflammatory bowel disease

1 finding from 1 review

Vitamin D for the treatment of inflammatory bowel disease 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 46 participants
Very low

High‐volume continuous veno‐venous hemofiltration (CVVH) vs standard CVVH

Quality of life · adults with severe acute pancreatitis

The review found no eligible studies for this question.

1 finding from 1 review

Continuous veno‐venous hemofiltration for severe acute pancreatitis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Discontinuation with high‐intensity psychological interventions vs continuation

Quality of life · participants with long‐term antidepressants for depressive disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 455 participants
Very low

Prophylactic platelet transfusions with high‐dose schedule vs standard‐dose strategies

Quality of life ‐ not reported · People with a haematological disorder

The review found no eligible studies for this question.

1 finding from 1 review

Different doses of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Higher dental caries experience vs Caries-free controls

Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years

Higher dental caries experience was associated with substantially higher odds of poor OHRQoL (OR 1.66, 95% CI 1.43-1.88; 6 studies; high heterogeneity I2=83.5%; ungraded).

1 finding from 1 review

The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… 2020 All outcomes
Upper-middle-income countries (5 studies) and one high-income country; studies 2011-2017
OR 1.66 [1.43, 1.88]
6 studies
GRADE not reported

Neoadjuvant immunotherapy (high dose interferon) plus chemotherapy vs neoadjuvant chemotherapy

Quality of life ‐ not reported · stage III and IV cutaneous melanoma

The review found no eligible studies for this question.

1 finding from 1 review

Neoadjuvant treatment for stage III and IV cutaneous melanoma 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Higher parental / maternal education vs Lower parental education (reference)

Oral health-related quality of life · Adolescents (10-19 years)

Higher parental education is associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

1 finding from 1 review

Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
Adolescents from families with higher incomes and higher levels of maternal education have better OHRQoL scores [34]. Children from families with high income, parental education and family economy had better OHRQoL [42].
Studies not reported
GRADE not reported

Higher family income / socioeconomic status vs Lower income / worse socioeconomic status

Oral health-related quality of life · Adolescents (10-19 years)

Higher family income / better socioeconomic status is associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

1 finding from 1 review

Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
Adolescents from families with higher incomes and higher levels of maternal education have better OHRQoL scores [34]. Worse oral health status, older age, female sex and worse socioeconomic status were significantly…
Studies not reported
GRADE not reported

Closing wedge high tibial osteotomy (CW‐HTO) vs unicompartmental knee arthroplasty

Health‐related quality of life measures Participant opinion: improvement · patients with osteoarthritis of the knee

The review found no eligible studies for this question.

1 finding from 1 review

Osteotomy for treating knee osteoarthritis 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found