Caregivers' preferences for oral hygiene care · Critically ill patients (adults and children) receiving mechanical ventilation in ICU
The review found no eligible studies for this question.
1 finding from 1 review
Plaque index (PI) / oral hygiene · Critically ill patients (adults and children) receiving mechanical ventilation in ICU
1 finding from 1 review
Incidence of VAP · Critically ill patients (adults and children) receiving mechanical ventilation in ICU
Chlorhexidine (mouthrinse or gel), as part of oral hygiene care probably leads to lower incidence of VAP compared with placebo or usual care (moderate certainty).
1 finding from 1 review
Adverse effects · Critically ill patients (adults and children) receiving mechanical ventilation in ICU
1 finding from 1 review
All‐cause mortality · Critically ill patients (adults and children) receiving mechanical ventilation in ICU
Chlorhexidine (mouthrinse or gel), as part of oral hygiene care showed no clear difference in mortality compared with placebo or usual care (moderate certainty).
1 finding from 1 review
Duration of mechanical ventilation · Critically ill patients (adults and children) receiving mechanical ventilation in ICU
It is very uncertain whether chlorhexidine (mouthrinse or gel), as part of oral hygiene care changes duration of mechanical ventilation compared with placebo or usual care (very low certainty).
1 finding from 1 review
Duration of ICU stay · Critically ill patients (adults and children) receiving mechanical ventilation in ICU
Chlorhexidine (mouthrinse or gel), as part of oral hygiene care showed no clear difference in duration of ICU stay compared with placebo or usual care (low certainty).
1 finding from 1 review
Cost / economic data · Critically ill patients (adults and children) receiving mechanical ventilation in ICU
The review found no eligible studies for this question.
1 finding from 1 review
Duration of systemic antibiotic use · Critically ill patients (adults and children) receiving mechanical ventilation in ICU
Chlorhexidine (mouthrinse or gel), as part of oral hygiene care showed no clear difference in duration of systemic antibiotic use compared with placebo or usual care; GRADE not reported.
1 finding from 1 review
Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
Chlorhexidine (CHX) led to lower reduction in level of contamination by particles >5 um (droplets) at… compared with essential oils/herbal mouthwash; GRADE not reported.
4 findings from 1 review
MD -44.1 [-59.12, -29.08]
1 study · 20 participants
GRADE not reported
Bay 1993 compared 0.12% CHX with essential oil mouthwash C (Listerine) at pharynx level (Andersen's level 2), which was considered patient level and hence was not analysed. No pooled estimate or GRADE rating.
1 study
GRADE not reported
MD -12.21 [-15.58, -8.83]
3 studies · 76 participants
Low
Show 1 more finding
Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles >5 um (droplets) at… compared with cetylpyridinium chloride (CPC) (very low certainty).
9 findings from 1 review
MD 8.8 [2.7, 14.9]
1 study · 20 participants
Very low
MD 17.4 [11.3, 23.5]
1 study · 20 participants
Very low
MD -11.5 [-18.37, -4.63]
1 study · 20 participants
Very low
Show 6 more findings
MD -8.8 [-14.9, -2.7]
1 study · 20 participants
Very low
MD -2.2 [-9.07, 4.67]
1 study · 20 participants
Very low
MD -30 [-85.86, 25.86]
1 study · 30 participants
Very low
MD -0.2 [-6.3, 5.9]
1 study · 20 participants
Very low
MD 13.6 [6.73, 20.47]
1 study · 20 participants
Very low
MD 4.43 [-2.27, 11.13]
2 studies · 50 participants
Very low
Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
5 findings from 1 review
At operator level, because of high heterogeneity (I2 = 98%), the results were not meta-analysed (6 studies, 196 participants). No pooled estimate or GRADE rating.
6 studies · 196 participants
GRADE not reported
MD -632.94 [-1267.33, 1.45]
3 studies · 80 participants
Very low
MD -101.1 [-107.01, -95.19]
1 study · 20 participants
Low
Show 2 more findings
Bay 1993 compared 0.12% CHX with distilled water (30-second rinse) and evaluated the outcome at patient level (Andersen's level 2, oropharynx); the data were not included in the meta-analysis. No pooled estimate or…
1 study
GRADE not reported
At assistant level, because of high heterogeneity (I2 = 96%), the results were not meta-analysed (4 studies, 136 participants). No pooled estimate or GRADE rating.
4 studies · 136 participants
GRADE not reported
Reduction in level of contamination by particles <=5 um (droplet nuclei) at >=2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles <=5 um (droplet… compared with povidone iodine (very low certainty).
2 findings from 1 review
Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles >5 um (droplets) at… compared with ozonated water (very low certainty).
1 finding from 1 review
Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
Chlorhexidine (CHX) led to lower reduction in level of contamination by particles >5 um (droplets) at… compared with saline; GRADE not reported.
2 findings from 1 review
MD -668.4 [-1044.45, -292.35]
1 study · 20 participants
GRADE not reported
MD -21.33 [-36.8, -5.86]
1 study · 12 participants
Very low
Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles >5 um (droplets) at… compared with boric acid (very low certainty).
2 findings from 1 review
MD -8.03 [-9.65, -6.41]
1 study · 60 participants
Very low
MD -26.6 [-28.24, -24.96]
1 study · 60 participants
Very low
Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles >5 um (droplets) at… compared with povidone iodine (very low certainty).
2 findings from 1 review
Reduction in level of contamination by particles <=5 um (droplet nuclei) at >=2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles <=5 um (droplet… compared with ozonated water (very low certainty).
2 findings from 1 review
Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
1 finding from 1 review
At operator level, because of high heterogeneity (I2 = 89%), which could not be explained, the results were not meta-analysed (2 studies, 60 participants; Feres 2010, Retamal-Valdes 2017). No pooled estimate or GRADE…
2 studies · 60 participants
GRADE not reported
Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
It is very uncertain whether tempered chlorhexidine changes reduction in level of contamination by particles >5 um (droplets) at… compared with non-tempered chlorhexidine (very low certainty).
3 findings from 1 review
MD -10.8 [-15.15, -6.45]
1 study · 20 participants
Very low
MD -17.6 [-23.7, -11.5]
1 study · 20 participants
Very low
MD -15.8 [-22.67, -8.93]
1 study · 20 participants
Very low