Question · asked by 1 review

Chlorhexidine (mouthrinse or gel), as part of oral hygiene care vs placebo or usual care: All‐cause mortality

Population
Critically ill patients (adults and children) receiving mechanical ventilation in ICU
Intervention
Chlorhexidine (mouthrinse or gel), as part of oral hygiene care
Comparison
placebo or usual care
Outcome
All‐cause mortality

Chlorhexidine (mouthrinse or gel), as part of oral hygiene care showed no clear difference in mortality compared with placebo or usual care (moderate certainty).

What each review found

Include earlier review versions
FindingEffectStudiesGRADE certainty
Chlorhexidine (mouthrinse or gel), as part of oral hygiene care vs Placebo or usual care
Mortality · Critically ill patients (adults and children) receiving mechanical ventilation in ICU · Follow-up: mean 1 month
Chlorhexidine (mouthrinse or gel), as part of oral hygiene care showed no clear difference in mortality compared with placebo or usual care (moderate certainty).
Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia (2020) · Cochrane All outcomes
RR 1.03 [0.80, 1.33]9 studies · 944 participantsModerate

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia
2020 · Cochrane All outcomes
2020-02Not listedNot assessed
How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.