Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

179 questions · 209 findings · 31 reviews

No studies found 35 · 16.7%GRADE not reported 68 · 32.5%Very low 67 · 32.1%Low 18 · 8.6%Moderate 16 · 7.7%High 5 · 2.4%

Chlorhexidine vs non‐antibacterial

Time to complete healing · people with burns

Chlorhexidine showed no clear difference in wound healing: time to complete healing (time‐to‐event data):… compared with non‐antibacterial (low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    HR 0.71 [0.39, 1.29]
    1 study · 51 participants
    Low

Chlorhexidine vs non‐antibacterial

Wound healing · people with burns

Chlorhexidine may leads to higher wound healing (mean time to healing): chlorhexidine versus… compared with non‐antibacterial (low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    MD 4.08 [0.73, 7.43]
    1 study · 51 participants
    Low

Chlorhexidine vs non‐antibacterial

Infection: chlorhexidine versus no antimicrobial/no additional antimicrobial · people with burns

It is very uncertain whether chlorhexidine changes infection: chlorhexidine versus no antimicrobial/no additional… compared with non‐antibacterial (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 1.11 [0.54, 2.27]
    2 studies · 172 participants
    Very low

Chlorhexidine vs non‐antibacterial

Adverse events: chlorhexidine versus hydrocolloid · people with burns

It is very uncertain whether chlorhexidine changes adverse events: chlorhexidine versus hydrocolloid compared with non‐antibacterial (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 0.2 [0.02, 1.65]
    1 study · 98 participants
    Very low

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ overall comparison between chlorhexidine and povidone‐iodine (during in‐patient stay) · patients with a central venous catheter

It is very uncertain whether chlorhexidine changes catheter‐related BSI ‐ overall comparison between chlorhexidine and… compared with povidone‐iodine (very low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ subgroup: chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution · patients with a central venous catheter

It is very uncertain whether chlorhexidine changes catheter‐related BSI ‐ subgroup: chlorhexidine in aqueous solution… compared with povidone‐iodine (very low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus povidone‐iodine in aqueous solution · patients with a central venous catheter

It is very uncertain whether chlorhexidine changes catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus… compared with povidone‐iodine (very low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus povidone‐iodine in alcohol · patients with a central venous catheter

Chlorhexidine showed no clear difference in catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus… compared with povidone‐iodine (moderate certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

All‐cause mortality ‐ Chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution Clinical assessment · patients with a central venous catheter

Chlorhexidine showed no clear difference in all‐cause mortality ‐ Chlorhexidine in aqueous solution versus… compared with povidone‐iodine (low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

All‐cause mortality ‐ Chlorhexidine in alcohol versus povidone‐iodine in aqueous solution Clinical assessment · patients with a central venous catheter

Chlorhexidine showed no clear difference in all‐cause mortality ‐ Chlorhexidine in alcohol versus… compared with povidone‐iodine (low certainty).

1 finding from 1 review

Antimicrobial coolant A (chlorhexidine) vs Distilled water coolant

Reduction in level of contamination in aerosols (CFU): chlorhexidine coolant vs distilled water during ultrasonic scaling · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether chlorhexidine coolant changes reduction in level of contamination in aerosols (CFU): chlorhexidine… compared with distilled water coolant (very low certainty).

1 finding from 1 review