Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

276 questions · 296 findings · 37 reviews

No studies found 41 · 13.9%GRADE not reported 88 · 29.7%Very low 45 · 15.2%Low 74 · 25%Moderate 39 · 13.2%High 9 · 3%

Calcium supplementation/fortification vs placebo or no intervention

Low birthweight · healthy pregnant women receiving calcium supplementation vs placebo or no treatment

Calcium supplementation showed no clear difference in low birthweight (< 2500 g) compared with placebo or no treatment (maternal outcomes) (moderate certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Persons with hypercalcaemia ‐ Vitamin D (D2, D3 or 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium showed no clear difference in persons with hypercalcaemia ‐ Vitamin D (D2, D3 or 25(OH)D) plus… compared with control or placebo (low certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Persons with renal disease (calculi or insufficiency) ‐ Vitamin D (D2, D3 or 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to higher persons with renal disease (calculi or insufficiency) ‐ Vitamin D… compared with control or placebo (high certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Deaths ‐ Vitamin D (D2, D3, 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium showed no clear difference in deaths ‐ Vitamin D (D2, D3, 25(OH)D) plus calcium (1 year estimate) compared with control or placebo (high certainty).

1 finding from 1 review

Oral calcium vs no treatment

Frequency of leg cramps after treatment: never · treating leg cramps in pregnancy

It is very uncertain whether oral calcium changes frequency of leg cramps after treatment: never compared with no treatment (very low certainty).

2 findings from 1 review

Oral calcium vs vitamin C

Frequency of leg cramps after treatment: never · treating leg cramps in pregnancy

It is very uncertain whether oral calcium changes frequency of leg cramps after treatment: never compared with oral vitamin C (very low certainty).

1 finding from 1 review

Calcium antagonists vs placebo

Death or dependency at end of · people with acute ischemic stroke

Calcium antagonists showed no clear difference in death or dependency at end of compared with placebo (moderate certainty).

1 finding from 1 review

Calcium antagonists vs placebo

Death at the end of treatment · people with acute ischemic stroke

Calcium antagonists showed no clear difference in death at the end of treatment compared with placebo (moderate certainty).

1 finding from 1 review

Calcium antagonists vs placebo

Recurrence of stroke at the end of · people with acute ischemic stroke

Calcium antagonists showed no clear difference in recurrence of stroke at the end of compared with placebo (moderate certainty).

1 finding from 1 review

Calcium antagonists vs placebo

Adverse events during treatment period · people with acute ischemic stroke

Calcium antagonists showed no clear difference in adverse events during treatment period compared with placebo (moderate certainty).

1 finding from 1 review

Calcium antagonists vs placebo

Systolic blood pressure · people with acute ischemic stroke

Calcium antagonists showed no clear difference in mean systolic blood pressure during or at end of treatment compared with placebo (low certainty).

1 finding from 1 review

Hydraulic calcium silicate cements (HCSC; MTA or Biodentine) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible pulpitis, undergoing…

At 36-month follow-up, HCSC show higher odds of clinical and radiographic success than CaOH (OR 2.34, 95% CI 1.43 to 3.84; ungraded subgroup).

3 findings from 1 review