Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

125 questions · 130 findings · 16 reviews

No studies found 25 · 19.2%GRADE not reported 10 · 7.7%Very low 28 · 21.5%Low 29 · 22.3%Moderate 27 · 20.8%High 11 · 8.5%

Botulinum toxin type A vs botulinum toxin type B

Adverse events: sore throat/dry mouth № of participants: 212 (2 RCTs) · adults with cervical dystonia

Botulinum toxin type A probably leads to higher adverse events: sore throat/dry mouth № of participants: 212 (2 RCTs) compared with botulinum toxin type B (moderate certainty).

1 finding from 1 review

Botulinum toxin vs surgery

Improved or corrected strabismusa at 6 or 12 months · adults and children with strabismus

Botulinum toxin may leads to lower improved or corrected strabismusa at 6 or 12 months compared with surgery (low certainty).

1 finding from 1 review

Botulinum toxin vs surgery

Proportion of participants requiring additional surgery(ies) at 6 or 12 months · adults and children with strabismus

It is very uncertain whether botulinum toxin changes proportion of participants requiring additional surgery(ies) at 6 or… compared with surgery (very low certainty).

1 finding from 1 review

Botulinum toxin vs surgery

Proportion of participants who achieved binocular single vision at 6 or 12 months · adults and children with strabismus

Botulinum toxin showed no clear difference in proportion of participants who achieved binocular single vision at 6… compared with surgery (low certainty).

1 finding from 1 review