Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

99 questions · 101 findings · 11 reviews

No studies found 29 · 28.7%GRADE not reported 3 · 3%Very low 48 · 47.5%Low 20 · 19.8%Moderate 1 · 1%High 0 · 0%

SSRI antidepressants vs tricyclic antidepressants (TCAs)

Drop‐out Objective · Adults with mental disorders in low‐ and middle‐income countries

It is very uncertain whether SSRI antidepressants changes drop‐outs (12 weeks) compared with TCA (very low certainty).

1 finding from 1 review

Tricyclic antidepressants vs placebo

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether tricyclic antidepressants changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).

1 finding from 1 review

New‐generation antidepressants vs placebo

Repetition of SH at post‐intervention · self‐harm in adults

It is very uncertain whether newer generation antidepressants (NGAs) changes repetition of SH by post‐intervention (NGA class)№ of participants:… compared with placebo (very low certainty).

3 findings from 1 review