Cochrane · systematic review · CD011777
Pharmacological interventions for self‐harm in adults
Hawton, K, Witt, KG, Taylor Salisbury, TL, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 40%Low 3 · 60%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Newer generation antidepressants versus placebo
Population: adults who engage in SH
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Repetition of SH at last Newer generation antidepressants vs placebo | OR 0.76 [0.42, 1.36] | 3 studies · 243 participants | Low Downgraded: risk of bias, imprecision |
Antipsychotics versus placebo or another comparator drug/dose
Population: adults who engage in SH
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Repetition of SH at six months (flupenthixol vs. placebo) Antipsychotics vs placebo or another comparator drug/dose | OR 0.09 [0.02, 0.5] | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision |
Repetition of SH at six months (low dose fluphenazine vs. ultra low dose fluphenazine) Antipsychotics vs placebo or another comparator drug/dose | OR 1.51 [0.5, 4.58] | 1 study · 53 participants | Very low Downgraded: risk of bias, imprecision |
Mood stabilisers versus placebo
Population: adults who engage in SH
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Repetition of SH at 12 months Mood stabilisers vs placebo | OR 0.99 [0.33, 2.95] | 1 study · 167 participants | Low Downgraded: risk of bias |
Natural products versus placebo
Population: adults who engage in SH
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Repetition of SH during 12 week treatment phase Natural products vs placebo | OR 1.33 [0.38, 4.62] | 1 study · 49 participants | Low Downgraded: risk of bias, imprecision |