Overall drop‐out rates (excluding deaths) at 12 months · older people in remission from depression
Antidepressant medication showed no clear difference in overall drop‐out rates (excluding deaths) at 12 months compared with placebo at 12 months' follow‐up (low certainty).
1 finding from 1 review
Treatment success (caries lesion arrest or restoration survival) · children (4 to 18 years) with functional abdominal pain disorders
Antidepressant showed no clear difference in treatment success compared with placebo (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · children (4 to 18 years) with functional abdominal pain disorders
Antidepressant showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).
1 finding from 1 review
Suicide completionCompleted suicide rates · patients with depressive disorders in children and adolescents
1 finding from 1 review
Remission or response (as defined in trial) · patients with depressive disorders in children and adolescents
Second generation antidepressant probably leads to higher remission or response (as defined in trial) compared with placebo (by medication) (moderate certainty).
1 finding from 1 review
Suicide‐related outcomes Timing of outcome assessment: end of treatment (6 to 12 weeks treatment duration) · patients with depressive disorders in children and adolescents
Second generation antidepressant may leads to higher suicide‐related outcome compared with placebo (by medication) (low certainty).
1 finding from 1 review
Leaving the study early · adults with psychotic depression
It is very uncertain whether antidepressant plus antipsychotic changes overall dropouts compared with placebo (very low certainty).
1 finding from 1 review
Quality of life · adults with psychotic depression
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability ‐ dropouts due to adverse effects · adults with psychotic depression
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Leaving the study early · adults with psychotic depression
It is very uncertain whether antidepressant plus antipsychotic changes overall dropouts compared with placebo plus antipsychotic (very low certainty).
1 finding from 1 review
Quality of life · adults with psychotic depression
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability ‐ dropouts due to adverse effects · adults with psychotic depression
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Dropout · women of any age, with PND up to 12 months
It is very uncertain whether antidepressants changes treatment acceptability ‐ dropouts (early phase, < 5 weeks) compared with treatment (very low certainty).
1 finding from 1 review
RR 1.71 [0.91, 3.23]
Studies not reported
Very low
Child‐related outcomes · women of any age, with PND up to 12 months
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · women of any age, with PND up to 12 months
Antidepressants may leads to lower adverse events compared with psychological interventions (low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Acceptability ‐ total dropouts · women of any age, with PND up to 12 months
It is very uncertain whether antidepressants changes treatment acceptability ‐ dropouts compared with psychological interventions (very low certainty).
1 finding from 1 review
RR 1.07 [0.24, 4.88]
Studies not reported
Very low
Child‐related outcomes · women of any age, with PND up to 12 months
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · women of any age, with PND up to 12 months
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability ‐ total dropouts · women of any age, with PND up to 12 months
It is very uncertain whether antidepressants changes treatment acceptability ‐ dropouts compared with psychosocial interventions (very low certainty).
1 finding from 1 review
RR 1.94 [1.12, 3.35]
Studies not reported
Very low
Child‐related outcomes · women of any age, with PND up to 12 months
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found