Second generation antidepressant vs placebo medication: Suicide‐related outcomes Timing of outcome assessment: end of treatment (6 to 12 weeks treatment duration)
Second generation antidepressant may leads to higher suicide‐related outcome compared with placebo (by medication) (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Second generation antidepressant vs placebo (by medication) Suicide‐related outcome · patients with depressive disorders in children and adolescents Second generation antidepressant may leads to higher suicide‐related outcome compared with placebo (by medication) (low certainty). Newer generation antidepressants for depressive disorders in children and adolescents (2012) · Cochrane Headline outcomes only | RR 1.58 [1.02, 2.45] | 17 studies · 3229 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Newer generation antidepressants for depressive disorders in children and adolescents 2012 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.