Serious adverse events between 0 and 16 weeks · predominantly knee osteoarthritis
Antidepressant showed no clear difference in serious adverse events between 0 and 16 weeks compared with placebo (low certainty).
1 finding from 1 review
Leaving the study early · adults with psychotic depression
It is very uncertain whether antidepressant changes overall dropouts compared with placebo (very low certainty).
1 finding from 1 review
Leaving the study early · adults with psychotic depression
It is very uncertain whether antidepressant changes overall dropouts compared with antipsychotic (very low certainty).
1 finding from 1 review
Quality of life · adults with psychotic depression
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability ‐ dropouts due to adverse effects · adults with psychotic depression
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life · adults with psychotic depression
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability ‐ dropouts due to adverse effects · adults with psychotic depression
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Dropout · adults living with HIV and depression
Antidepressant showed no clear difference in study dropouts at 6‐12 weeks compared with placebo (moderate certainty).
1 finding from 1 review
Quality of life score at 8 weeks · adults living with HIV and depression
1 finding from 1 review
Clinical global impression (response rate) ‐ desipramine · Children and adolescents with ADHD
Tricyclic antidepressants (TCAs) may leads to higher clinical global impression (response rate) ‐ desipramine compared with placebo (low certainty).
1 finding from 1 review
Leaving the study early · adults with psychotic depression
It is very uncertain whether antidepressant plus antipsychotic changes overall dropouts compared with placebo plus antidepressant (very low certainty).
2 findings from 1 review
Quality of life · adults with psychotic depression
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Acceptability ‐ dropouts due to adverse effects · adults with psychotic depression
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Efficacy as a continuous outcome · adults with cancer and depression
1 finding from 1 review
Efficacy as a dichotomous outcome · adults with cancer and depression
It is very uncertain whether antidepressants changes efficacy as a dichotomous outcome compared with placebo (very low certainty).
1 finding from 1 review
Acceptability ‐ total dropouts · adults with cancer and depression
It is very uncertain whether antidepressants changes dropouts due to any cause (acceptability) compared with placebo (very low certainty).
1 finding from 1 review
Percent of days abstinent · people with co‐occurring depression and alcohol dependence
1 finding from 1 review
Consumption of alcohol: abstinent participants (number) · people with co‐occurring depression and alcohol dependence
Antidepressants probably leads to higher consumption of alcohol: abstinent participants (number) compared with placebo: all studies (moderate certainty).
1 finding from 1 review
Amount of alcohol consumed, short term (3‐6 months) measured using the number of drinks/drinking day (in past week to 30 days) · people with co‐occurring depression and alcohol dependence
1 finding from 1 review
Acceptability ‐ total dropouts · people with co‐occurring depression and alcohol dependence
Antidepressants showed no clear difference in acceptability: dropouts compared with placebo: all studies (low certainty).
1 finding from 1 review