Cochrane · systematic review · CD006997
Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents
Otasowie, J, Castells, X, Ehimare, UP, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 33.3%Low 4 · 66.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Tricyclic antidepressants (TCAs) compared to placebo for attention deficit hyperactivity disorder (ADHD) in children and adolescents
Population: Children and adolescents with ADHD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Efficacy for ADHD symptoms (parents using a rating scale) ‐ desipramine Tricyclic antidepressants (TCAs) vs placebo | no estimate extracted | 2 studies · 99 participants | Low Downgraded: publication bias |
Efficacy for ADHD symptoms (teachers using a rating scale) ‐ desipramine Tricyclic antidepressants (TCAs) vs placebo | no estimate extracted | 2 studies · 89 participants | Low Downgraded: publication bias |
CGI (response rate) ‐ desipramine and nortriptyline Tricyclic antidepressants (TCAs) vs placebo | OR 18.5 [6.29, 54.39] | 3 studies · 125 participants | Low Downgraded: imprecision, publication bias |
Clinical global impression (response rate) ‐ desipramine Tricyclic antidepressants (TCAs) vs placebo | OR 26.41 [7.41, 94.18] | 2 studies · 103 participants | Low Downgraded: publication bias |
All‐cause treatment discontinuation ‐ desipramine Tricyclic antidepressants (TCAs) vs placebo | no estimate extracted | 3 studies · 134 participants | Very low Downgraded: imprecision, inconsistency, publication bias |
Desipramine compared to clonidine for ADHD in children and adolescents
Population: Children and adolescents with ADHD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Efficacy for ADHD symptoms (parent‐rated symptoms using VAS) Desipramine vs clonidine | no estimate extracted | 1 study · 68 participants | Very low |