Antidepressant plus antipsychotic vs placebo plus antidepressant: Leaving the study early
It is very uncertain whether antidepressant plus antipsychotic changes overall dropouts compared with placebo plus antidepressant (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antidepressant plus antipsychotic vs placebo plus antidepressant Overall dropouts · adults with psychotic depression It is very uncertain whether antidepressant plus antipsychotic changes overall dropouts compared with placebo plus antidepressant (very low certainty). Pharmacological treatment for psychotic depression (2021) · Cochrane Headline outcomes only | RR 0.91 [0.55, 1.5] | 4 studies · 245 participants | Very low |
Antidepressant plus antipsychotic vs placebo plus the same antidepressant Overall dropouts · adults with psychotic depression It is very uncertain whether antidepressant plus antipsychotic changes overall dropouts compared with placebo plus the same antidepressant (very low certainty). Pharmacological treatment for psychotic depression (2021) · Cochrane Headline outcomes only | RR 1.04 [0.52, 2.07] | 3 studies · 157 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.