Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

249 questions · 257 findings · 31 reviews

No studies found 52 · 20.2%GRADE not reported 5 · 1.9%Very low 81 · 31.5%Low 77 · 30%Moderate 34 · 13.2%High 8 · 3.1%

Antidepressants vs placebo

Number of responders · patients with depression and dementia

Antidepressant treatment showed no clear difference in number of responders (ITT) at 6 to 12 weeks compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Risk for at least one adverse event per patient · patients with depression and dementia

Antidepressant treatment probably leads to higher number of patients experiencing at least one adverse event compared with placebo (moderate certainty).

1 finding from 1 review