Cochrane · systematic review · CD003944
Antidepressants for treating depression in dementia
Dudas, R, Malouf, R, McCleery, J, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 4 · 57.1%High 2 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antidepressant treatment compared with placebo for depression in dementia
Population: patients with depression and dementia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Depression endpoint mean scores at 6 to 13 weeks Antidepressant treatment vs placebo | no estimate extracted | 8 studies · 614 participants | High |
Number of responders (ITT) at 6 to 12 weeks Antidepressant treatment vs placebo | OR 1.71 [0.8, 3.67] | 3 studies · 116 participants | Low Downgraded: imprecision, indirectness |
Number of patients with remission (ITT) at 6 to 12 weeks Antidepressant treatment vs placebo | OR 2.57 | 4 studies · 240 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Cognitive function endpoint mean scores at 6 to 12 weeks Antidepressant treatment vs placebo | no estimate extracted | 5 studies · 194 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Activities of daily living, endpoint values at 6 to 13 weeks Antidepressant treatment vs placebo | no estimate extracted | 4 studies · 173 participants | High |
Number of dropouts at 6 to 13 weeks Antidepressant treatment vs placebo | OR 1.51 [1.07, 2.14] | 9 studies · 836 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Number of patients experiencing at least one adverse event Antidepressant treatment vs placebo | OR 1.55 [1.21, 1.98] | 5 studies · 1073 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |