Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

888 questions · 936 findings · 109 reviews

No studies found 196 · 20.9%GRADE not reported 88 · 9.4%Very low 226 · 24.1%Low 217 · 23.2%Moderate 152 · 16.2%High 57 · 6.1%

Antibiotic prophylaxis vs no treatment

Infection rate at 2 weeks postpartum ‐ perineal wound infection in third‐ or fourth‐degree tear · Women with third‐ and fourth‐degree perineal tear during vaginal birth

Antibiotic prophylaxis probably leads to lower infection rate at 2 weeks postpartum ‐ perineal wound infection in… compared with no treatment (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis vs no treatment

Infection rate at 6 weeks postpartum ‐ perineal wound infection in third‐ or fourth‐degree tear · Women with third‐ and fourth‐degree perineal tear during vaginal birth

Antibiotic prophylaxis showed no clear difference in infection rate at 6 weeks postpartum ‐ perineal wound infection in… compared with no treatment (low certainty).

1 finding from 1 review

Antibiotics on removal of central venous catheter vs no antibiotics

Late‐onset blood steam infection · newborn infants undergoing removal of central venous catheter

Antibiotics on removal of central venous catheter showed no clear difference in late‐onset blood steam infection compared with no antibiotics (low certainty).

1 finding from 1 review

Antibiotics on removal of central venous catheter vs no antibiotics

Central line‐associated blood stream infection · newborn infants undergoing removal of central venous catheter

Antibiotics on removal of central venous catheter showed no clear difference in central line‐associated blood stream infection compared with no antibiotics (low certainty).

1 finding from 1 review

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Adverse events (moderate) · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics plus IV antibiotics changes adverse events moderate adverse events experienced during and after… compared with IV antibiotics only (very low certainty).

1 finding from 1 review

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Microbiology Emergence of resistant organisms · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics plus IV antibiotics changes microbiology Emergence of resistant organisms compared with IV antibiotics only (very low certainty).

1 finding from 1 review

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Quality of life: number of participants achieving MCID · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

Summary of findings: Inhaled antibiotics plus IV antibiotics showed no clear difference in quality of life: number of participants achieving MCID compared with IV antibiotics only (low certainty).

1 finding from 1 review