Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

888 questions · 936 findings · 109 reviews

No studies found 196 · 20.9%GRADE not reported 88 · 9.4%Very low 226 · 24.1%Low 217 · 23.2%Moderate 152 · 16.2%High 57 · 6.1%

Summary of findings: anti‐pseudomonal antibiotics vs placebo

Antibiotic resistance: frequency of tobramycin‐resistant P aeruginosa · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: anti‐pseudomonal antibiotics showed no clear difference in antibiotic resistance: frequency of tobramycin‐resistant P aeruginosa compared with placebo (moderate certainty).

1 finding from 1 review

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Development of antibiotic resistance · patients on maintenance HD with CRBSI

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (superficial perineal wound infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics leads to lower infected episiotomy/laceration (superficial perineal wound… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (deep perineal wound infection № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics leads to lower infected episiotomy/laceration (deep perineal wound infection № of… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (organ or space infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics showed no clear difference in infected episiotomy/laceration (organ or space infection) № of… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (wound breakdown) № of participants: 2593 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics probably leads to lower infected episiotomy/laceration (wound breakdown) № of participants:… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review