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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

Comparison

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Review versions

387 questions in 55 reviews · Common Mental Disorders

current versions

No studies 387 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
Psychological therapy vs control Somatic symptoms and related disorders · children exposed to traumatic events Psychological therapies for the treatment of mental disorders in low‐ and middle‐income countries affected… (2018) · Cochrane	no estimate extracted	NR	No studies
Psychological therapy vs control Somatic symptoms and related disorders · adults exposed to traumatic events Psychological therapies for the treatment of mental disorders in low‐ and middle‐income countries affected… (2018) · Cochrane	no estimate extracted	NR	No studies
Psychological therapy vs control Depression at endpoint · children exposed to traumatic events Psychological therapies for the treatment of mental disorders in low‐ and middle‐income countries affected… (2018) · Cochrane	no estimate extracted	NR	No studies
Psychological therapy vs control Anxiety at endpoint · children exposed to traumatic events Psychological therapies for the treatment of mental disorders in low‐ and middle‐income countries affected… (2018) · Cochrane	no estimate extracted	NR	No studies
Selective serotonin reuptake inhibitor vs placebo Change in hospital utilisation ‐ not measured · chronic obstructive pulmonary disease (COPD) with depression Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease (2018) · Cochrane	no estimate extracted	NR	No studies
Tricylic antidepressant vs placebo Change in hospital utilisation ‐ not measured · COPD with depression Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease (2018) · Cochrane	no estimate extracted	NR	No studies
Psychological therapy vs any comparator Dropouts due to adverse events · anxiety and depression in children and adolescents with long‐term physical conditions Psychological therapies for anxiety and depression in children and adolescents with long‐term physical… (2018) · Cochrane	no estimate extracted	NR	No studies
Psychological therapy vs any comparator Suicide‐related behaviour · anxiety and depression in children and adolescents with long‐term physical conditions Psychological therapies for anxiety and depression in children and adolescents with long‐term physical… (2018) · Cochrane	no estimate extracted	NR	No studies
Music therapy vs psychological treatment Any adverse events ‐ not reported · adults with depression Music therapy for depression (2017) · Cochrane	no estimate extracted	NR	No studies
Music therapy vs psychological treatment Functioning ‐ not reported · adults with depression Music therapy for depression (2017) · Cochrane	no estimate extracted	NR	No studies
Music therapy vs psychological treatment Anxiety ‐ not reported · adults with depression Music therapy for depression (2017) · Cochrane	no estimate extracted	NR	No studies
Active music therapy vs receptive music therapy Any adverse events ‐ not reported · adults with depression Music therapy for depression (2017) · Cochrane	no estimate extracted	NR	No studies
Active music therapy vs receptive music therapy Functioning ‐ not reported · adults with depression Music therapy for depression (2017) · Cochrane	no estimate extracted	NR	No studies
Active music therapy vs receptive music therapy Anxiety ‐ not reported · adults with depression Music therapy for depression (2017) · Cochrane	no estimate extracted	NR	No studies
Topiramate as add‐on therapy vs placebo Efficacy: change in scores from baseline to endpoint on symptom rating scales in the treatment of depressive episodes · adults with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate as add‐on therapy vs placebo Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in depressive episodes · adults with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate as add‐on therapy vs placebo Remission with topiramate. Number of participants presenting with a rating scale score within the normal range at the endpoint in manic and mixed episodes · adults with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate as add‐on therapy vs placebo Remission with topiramate. Number of participants presenting with a rating scale score within the normal range at the endpoint in depressive episodes · adults with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate as monotherapy vs an alternative drug Efficacy: change in scores from baseline to endpoint on symptom rating scales in the treatment of depressive episodes · adults with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate as monotherapy vs an alternative drug Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate as monotherapy vs an alternative drug Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in depressive episodes · adults with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate as monotherapy vs an alternative drug Remission with topiramate. Number of participants presenting with a rating scale score within the normal range at the endpoint in manic and mixed episodes · adults with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate as monotherapy vs an alternative drug Remission with topiramate. Number of participants presenting with a rating scale score within the normal range at the endpoint in depressive episodes · adults with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate as add‐on therapy vs alternative drug Efficacy: change in scores from baseline to endpoint on symptom rating scales in the treatment of manic and mixed episodes · people with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate as add‐on therapy vs alternative drug Efficacy: change in scores from baseline to endpoint on symptom rating scales in the treatment of depressive episodes · people with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate as add‐on therapy vs alternative drug Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · people with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate as add‐on therapy vs alternative drug Remission with topiramate as add‐on therapy. Number of participants presenting with a rating scale score within the normal range at the endpoint in manic and mixed episodes · people with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate vs placebo Efficacy: change in scores from baseline to endpoint on symptom rating scales in the treatment of depressive episodes · adults with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate vs placebo Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate vs placebo Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in depressive episodes · adults with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate vs placebo Remission with topiramate. Number of participants presenting with a rating scale score within the normal range at the endpoint in manic and mixed episodes · adults with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Topiramate vs placebo Remission with topiramate. Number of participants presenting with a rating scale score within the normal range at the endpoint in depressive episodes · adults with acute affective episodes in bipolar disorder Topiramate for acute affective episodes in bipolar disorder in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Non‐trauma‐focused psychological intervention for PTSD and SUD or PTSD only vs control intervention Treatment completers ‐ Individual‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder Psychological therapies for post‐traumatic stress disorder and comorbid substance use disorder (2016) · Cochrane	no estimate extracted	NR	No studies
Non‐trauma‐focused psychological intervention for PTSD and SUD or PTSD only vs control intervention Drug or alcohol use, or both following treatment completion ‐ Individual‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder Psychological therapies for post‐traumatic stress disorder and comorbid substance use disorder (2016) · Cochrane	no estimate extracted	NR	No studies
Cognitive behaviour therapy vs no treatment Long‐term remission/response ( · adult patients with panic disorder with or without agoraphobia Psychological therapies for panic disorder with or without agoraphobia in adults: a network meta‐analysis (2016) · Cochrane	no estimate extracted	NR	No studies
Treatment informed by feedback of patient reported outcome measures vs treatment Outcomes and length of · People with common mental health disorders1 Routine use of patient reported outcome measures (PROMs) for improving treatment of common mental health… (2016) · Cochrane	no estimate extracted	NR	No studies
Treatment informed by feedback of patient reported outcome measures vs treatment CI: Confidence interval · People with common mental health disorders1 Routine use of patient reported outcome measures (PROMs) for improving treatment of common mental health… (2016) · Cochrane	no estimate extracted	NR	No studies
S‐adenosyl methionine as monotherapy vs SSRI antidepressant agent Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with depression S‐adenosyl methionine (SAMe) for depression in adults (2016) · Cochrane	no estimate extracted	NR	No studies
S‐adenosyl methionine as adjunctive treatment vs placebo Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with depression S‐adenosyl methionine (SAMe) for depression in adults (2016) · Cochrane	no estimate extracted	NR	No studies
S‐adenosyl methionine as monotherapy vs placebo Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with depression S‐adenosyl methionine (SAMe) for depression in adults (2016) · Cochrane	no estimate extracted	NR	No studies
S‐adenosyl methionine as monotherapy vs tricyclic antidepressant agent Proportions of participants achieving remission Depression rating scale score within the normal range at the end of the study · adults with depression S‐adenosyl methionine (SAMe) for depression in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Therapist‐supported ICBT vs face‐to‐face CBT Adverse events at post‐treatment ‐ not reported · adults with anxiety disorders Therapist‐supported Internet cognitive behavioural therapy for anxiety disorders in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Comparison 2: Interventions for multiple repetition of SH/probable personality disorder vs treatment DBT vs TAU · adults who engage in SH Psychosocial interventions for self‐harm in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Comparison 6: Remote contact interventions vs treatment Postcards vs TAU · adults who engage in SH Psychosocial interventions for self‐harm in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Comparison 6: Remote contact interventions vs treatment Emergency cards vs TAU · adults who engage in SH Psychosocial interventions for self‐harm in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Comparison 6: Remote contact interventions vs treatment Telephone contact vs TAU · adults who engage in SH Psychosocial interventions for self‐harm in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Comparison 2: Interventions for multiple repetition of SH/probable personality disorder vs treatment Mentalisation vs TAU · adults who engage in SH Psychosocial interventions for self‐harm in adults (2016) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Prevalence of psychological trauma (short term: up to 3 months postpartum) Measured by various scales ‐ Impact of Event Scale (IES), MINI‐PTSD · Women of any age who had given birth within one month of the intervention being offered Debriefing interventions for the prevention of psychological trauma in women following childbirth (2015) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Prevalence of depression or depressive symptoms (short term: up to 3 months postpartum) Measured by various scales ‐ EPDS, HADS · Women of any age who had given birth within one month of the intervention being offered Debriefing interventions for the prevention of psychological trauma in women following childbirth (2015) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Prevalence of anxiety (short term: up to 3 months postpartum) Measured by HADS · Women of any age who had given birth within one month of the intervention being offered Debriefing interventions for the prevention of psychological trauma in women following childbirth (2015) · Cochrane	no estimate extracted	NR	No studies