What do systematic reviews say?

Time to occurrence of acute URTI ‐ not reported · children up to the age of 7 at risk of upper respiratory tract infection

Number of cases with complications ‐ not reported · children up to the age of 7 at risk of upper respiratory tract infection

Rate of hospitalisation ‐ not reported · children up to the age of 7 at risk of upper respiratory tract infection

Relief of pain · children with acute postoperative pain

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

Relief of pain · children with acute postoperative pain

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · children with acute postoperative pain

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

Relief of pain · children with acute postoperative pain

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · children with acute postoperative pain

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

Relief of pain · children with acute postoperative pain

Frequency of intervention‐related non‐ocular adverse events ( · people with primary macula‐involving rhegmatogenous retinal detachments

Hospital stay — not reported · patients requiring haemodialysis

Hospital stay — not reported · patients requiring haemodialysis

Virologically confirmed dengue case incidence (any severity, any phenotype) · children and adults at risk of dengue infection

Prevalence of dengue RNA in the mosquito population · children and adults at risk of dengue infection

Mosquito density (for population suppression strategy) · children and adults at risk of dengue infection

Prevalence of Wolbachia‐carrying mosquitoes (for population replacement strategy) · children and adults at risk of dengue infection