What do systematic reviews say?

FEV1 · acute exacerbations of chronic obstructive pulmonary disease

Other adverse effects (gastrointestinal upset, headache, allergic reaction) · adults with tinnitus

Serious adverse effects (bleeding or seizures) · adults with tinnitus

Health‐related quality of life · adults with tinnitus

Presence or absence of urinary urgency · Adults with overactive bladder (OAB)

Episodes of urinary incontinence in a 24‐hour period · Adults with overactive bladder (OAB)

Daytime urinary frequency · Adults with overactive bladder (OAB)

Episodes of nocturia · Adults with overactive bladder (OAB)

Proportion of initially unaffected fellow eyes that had signs/symptoms of infection within 7 days of onset of signs/symptoms in the first eye (lower is favored) · epidemic keratoconjunctivitis

Proportion of participants with resolution of signs within 7 days of treatment (higher is favored) · epidemic keratoconjunctivitis

Proportion of participants in whose eyes SEI had disappeared within 21 days of treatment (higher is favored) · epidemic keratoconjunctivitis

Proportion of participants who discontinued medication and did not develop rebound SEI within 21 days (higher is favored) · epidemic keratoconjunctivitis

Proportion of initially unaffected fellow eyes that had signs/symptoms of infection within 7 days of onset of signs/symptoms in the first eye (lower is favored) · epidemic keratoconjunctivitis

Proportion of participants who discontinued medication and did not develop rebound SEI within 21 days (higher is favored) · epidemic keratoconjunctivitis

Proportion of initially unaffected fellow eyes that had signs/symptoms of infection within 7 days of onset of signs/symptoms in the first eye (lower is favored) · epidemic keratoconjunctivitis

Overall survival · children and adults with Smith‐Lemli‐Opitz syndrome

QoL · children and adults with Smith‐Lemli‐Opitz syndrome

Complete abortion rate ‐ not reported · women having medical abortion before 14 weeks' gestation

Induction to expulsion interval ‐ not reported · women having medical abortion before 14 weeks' gestation

Unscheduled contact with care ‐ not reported · women having medical abortion before 14 weeks' gestation