What do systematic reviews say?

Serious adverse events: life‐threatening/ hospitalisation · adults with surgical wounds

Serious adverse events: life‐threatening/ hospitalisation · adults with surgical wounds

Participants with at least some Side Effects · community‐dwelling older adults ≥ 65 years of age

Serious adverse events during the study period · children with acute postoperative pain

Serious adverse events during the study period · children with acute postoperative pain

Patient (dichotomous) outcomes (including adverse events) · Healthcare professionals (nurses, primary care physicians)

Patient (dichotomous) outcomes (including adverse events) · Healthcare professionals (nurses, physicians including obstetricians)

Withdrawals due to adverse events · patients with osteoarthritis

Withdrawals due to adverse events · patients with osteoarthritis

Adverse events, OHSS, preterm delivery, congenital anomaly · women with gonadotropin stimulation

Adverse events, OHSS, preterm delivery, congenital anomaly · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation

Adverse events, OHSS, preterm delivery, congenital anomaly · women with oral (clomiphene citrate or letrozole) stimulation

Adverse events, OHSS, preterm delivery, congenital anomaly · women trying to conceive by intrauterine insemination

Adverse events, OHSS, preterm delivery, congenital anomaly · women trying to conceive by intrauterine insemination

Adverse events, OHSS, preterm delivery, congenital anomaly · women trying to conceive by intrauterine insemination

Dropouts due to adverse events · adults with trichotillomania

Proportion of participants with ≥ 1 serious adverse events · people with acute subarachnoid haemorrhage

Proportion of participants with ≥ 1 serious adverse events · chronic hepatitis B

Proportion of participants with ≥ 1 serious adverse events · chronic hepatitis B

Adverse Events ‐ reported, but not analyzed in this review · Apathy in people with mild‐to‐moderate Alzheimer's disease