What do systematic reviews say?

Number of adverse events · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis

Adverse events (overall) · adults undergoing arthroscopically assisted ACL reconstruction1

Number of adverse events · people with primary sclerosing cholangitis

Adverse events: infection · adults with chronic pain

Adverse events: infection · adults with chronic pain

Grades 3 and 4 adverse events · non‐hospitalised individuals with COVID‐19 (asymptomatic and mild disease)

Adverse events: all cause · people with schizophrenia or other serious mental illness

Adverse events at 1‐month · people with dry eyea

Adverse events at 1 year' · participants with glaucoma or ocular hypertension

Non‐serious adverse events · people with resectable cholangiocarcinoma

Adverse events: all grades · non‐hospitalised individuals with COVID‐19 (asymptomatic and mild disease)

Serious adverse events (N) · people at increased risk for developing type 2 diabetes

Non‐serious adverse events · participants with β‐thalassaemia

Non‐serious adverse events · adults with oesophageal varices

Systemic adverse events at · adults with centre‐involving diabetic macular oedema

Systemic adverse events at · adults with centre‐involving diabetic macular oedema

Significant adverse events · people with inclusion body myositis

Secondary ‐ Adverse events · Patients with acute uncomplicated diverticulitis

Secondary ‐ Adverse events · Patients with acute uncomplicated diverticulitis

Adverse events To discharge · newborn infants with opioid withdrawal