What do systematic reviews say?

Relief of pain · children with acute postoperative pain

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

Relief of pain · children with acute postoperative pain

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · children with acute postoperative pain

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

Relief of pain · children with acute postoperative pain

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · children with acute postoperative pain

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

Relief of pain · children with acute postoperative pain

Recurrent seizure at 18 months · children with febrile seizures

Recurrent seizure at 36 months · children with febrile seizures

Recurrent seizure at 48 months · children with febrile seizures

Recurrent seizure at 60 months or greater · children with febrile seizures

Number of participants using rescue medication over 4 to 6 hours postinterventions · health problem or population

All‐cause mortality during hospital stay · preterm or low birth weight infants with PDA

Ibuprofen vs placebo

Gastrointestinal side effects (diarrhoea) ‐ not reported · women having medical abortion before 14 weeks' gestation

Induction to expulsion interval ‐ not reported · women having medical abortion before 14 weeks' gestation

Unscheduled contact with care ‐ not reported · women having medical abortion before 14 weeks' gestation