Disease-free survival · People with squamous cell carcinoma of the oral cavity or oropharynx
It is very uncertain whether non-specific immunotherapy (recombinant interleukin-2 or BCG cell… changes disease-free survival compared with standard therapy alone (very low certainty).
1 finding from 1 review
Progression‐free survival · People with squamous cell carcinoma of the oral cavity or oropharynx
EGFR monoclonal antibody (cetuximab or nimotuzumab) plus standard… showed no clear difference in progression-free survival compared with standard therapy alone (radiotherapy or chemoradiotherapy); GRADE not reported.
2 findings from 1 review
Pacifier withdrawal vs No treatment
Outcome not reported · Children with a non-nutritive sucking habit (digit or pacifier)
The review found no eligible studies for this question.
1 finding from 1 review
Oral mucositis (severe) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
1 finding from 1 review
Oral mucositis (severe). Not estimable - no participants had developed severe oral mucositis by the fourth day after chemotherapy when the data were reported (Zhang 2011, Analysis 4.3, subgroup 3.1); 118 participants…
1 study · 118 participants
GRADE not reported
Oral mucositis (moderate to severe) · Adults with solid cancers receiving fluorouracil (5FU) and leucovorin
It is very uncertain whether oral cryotherapy for 30 minutes changes oral mucositis (moderate to severe) compared with oral cryotherapy for 60 minutes (very low certainty).
1 finding from 1 review
Progression‐free survival · People with squamous cell carcinoma of the oral cavity or oropharynx
It is very uncertain whether tyrosine kinase inhibitor (erlotinib, gefitinib or lapatinib) plus… changes progression-free survival compared with standard therapy alone (radiotherapy or chemoradiotherapy) (very low certainty).
1 finding from 1 review
Participant satisfaction · People with squamous cell carcinoma of the oral cavity or oropharynx
The review found no eligible studies for this question.
1 finding from 1 review
Sucking cessation (short term) · Children with a non-nutritive sucking habit (digit or pacifier)
Orthodontic appliances (palatal arch/palatal crib) may leads to higher sucking cessation (short term) compared with no treatment (low certainty).
1 finding from 1 review
Other oral symptoms (oral discomfort, dysphonia) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Both studies assessed oral discomfort and dysphonia (Johnson 1993; LeVeque 1993); pilocarpine reported to improve associated symptoms of salivary gland dysfunction (oral discomfort, dysphonia). No pooled data.
2 studies · 278 participants
GRADE not reported
Occlusion (net change in overjet, short term) · Children with a non-nutritive sucking habit (digit or pacifier)
1 finding from 1 review
Table 1 (reduction in malocclusion), Villa 1997 (n=24), palatal crib vs no treatment: net change in overjet (mm) - no treatment 0.02; palatal crib -0.2; no statistically significant net change in overjet between…
1 study · 24 participants
GRADE not reported
Oral mucositis (mean severity on WHO 0 to 4 scale) · All patients with cancer who are receiving treatment
It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (mean severity on WHO 0 to 4 scale) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (very low certainty).
1 finding from 1 review
Root canal medications and canal filling, splinting, extraction of teeth, or surgical removal of any relevant pathology vs Each other, placebo, or no treatment
Outcome not reported · Patients with single and multiple permanent teeth with evidence of any type of external root resorption irrespective of its aetiology,…
The review found no eligible studies for this question.
1 finding from 1 review
None of the studies fulfilled our inclusion criteria and therefore no data analysis was conducted. (Main results: no RCTs that met the inclusion criteria were identified; one ongoing study, NCT00423956, potentially…
0 studies
No studies found
Patient satisfaction with treatment Measured by a validated scale · Individuals of any age receiving orthodontic treatment with fixed appliances (braces) (people requiring orthodontic tooth movement);…
The review found no eligible studies for this question.
1 finding from 1 review
Oral pain · All patients with cancer who are receiving treatment
3 findings from 1 review
Oral pain was assessed in this subgroup but the study (Kakoei 2013) did not report details of the scale used, so the data could not be used (no usable estimate).
1 study
GRADE not reported
MD -1.93 [-2.37, -1.49]
1 study · 80 participants
Very low
MD -1.5 [-2.11, -0.89]
2 studies · 85 participants
Low
Sucking cessation (short term) · Children with a non-nutritive sucking habit (digit or pacifier)
Psychological intervention + palatal arch led to lower sucking cessation (short term) compared with psychological intervention + palatal crib; GRADE not reported.
1 finding from 1 review
Overall survival · People with squamous cell carcinoma of the oral cavity or oropharynx
EGFR monoclonal antibody (cetuximab or nimotuzumab) plus standard… probably leads to lower overall survival compared with standard therapy alone (radiotherapy or chemoradiotherapy) (moderate certainty).
1 finding from 1 review
Overall survival · People with squamous cell carcinoma of the oral cavity or oropharynx
2 findings from 1 review
BCG-CWP + surgery versus surgery alone: 3-year overall survival 10/10 vs 9/10; too few participants to calculate a hazard ratio (Bier 1981, 24 participants).
1 study · 24 participants
GRADE not reported
HR 0.52 [0.31, 0.87]
1 study · 201 participants
Very low
Oral mucositis (any severity) · All patients with cancer who are receiving treatment
Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… showed no clear difference in oral mucositis (any severity) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (low certainty).
3 findings from 1 review
RR 0.59 [0.35, 1.01]
5 studies · 270 participants
Low
RR 0.61 [0.52, 0.72]
5 studies · 444 participants
Moderate
RR 0.98 [0.90, 1.07]
1 study · 122 participants
Very low
Number of days in hospital (duration of hospitalisation) · All patients with cancer who are receiving treatment
The review found no eligible studies for this question.
2 findings from 1 review
Sucking cessation (short term) · Children with a non-nutritive sucking habit (digit or pacifier)
Aversive tasting substance applied to digit showed no clear difference in sucking cessation (short term) compared with psychological intervention (habit reversal); GRADE not reported.
1 finding from 1 review