Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control): Oral pain
It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral pain compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs Control (no treatment or standard/usual oral care, e.g. saline rinse) Oral pain · All patients with cancer who are receiving treatment · Radiotherapy to the head and neck Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy (2015) · Cochrane All outcomes | Oral pain was assessed in this subgroup but the study (Kakoei 2013) did not report details of the scale used, so the data could not be used (no usable estimate). | 1 study | GRADE not reported |
Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs Control (no treatment or standard/usual oral care, e.g. saline rinse) Oral pain · All patients with cancer who are receiving treatment · Fluorouracil (5FU) treatment for solid cancers It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral pain compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (very low certainty). Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy (2015) · Cochrane All outcomes | MD -1.93 [-2.37, -1.49] | 1 study · 80 participants | Very low |
Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs Control (no treatment or standard/usual oral care, e.g. saline rinse) Oral pain · All patients with cancer who are receiving treatment · High-dose melphalan-based treatment prior to HSCT (haematological cancers) Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… may leads to lower oral pain compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (low certainty). Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy (2015) · Cochrane All outcomes | MD -1.5 [-2.11, -0.89] | 2 studies · 85 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes | 2015-06 | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.