Caries experience · European adolescents aged 16 years
Pooled caries experience was 3.29.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with symptomatic irreversible pulpitis due to carious pulp exposure
In symptomatic irreversible pulpitis, pooled pulpotomy success was 84% (95% CI 72-92%); not significantly different from asymptomatic (z=-1.34, p=0.18); ungraded.
1 finding from 1 review
Dentinal caries in permanent (newly erupted) teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)
Enamel caries in the primary dentition is associated with about 1.6 times higher odds of dentinal caries in permanent teeth (single study; not GRADE-rated).
1 finding from 1 review
Early childhood caries (ECC) - association at lead SNP rs74470773 (3:33958083; nearest gene(s) PDCD6IP) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs74470773 near PDCD6IP showed suggestive (not genome-wide significant) association with ECC (Z = -4.589, p = 4.46e-6); genetic association, ungraded.
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; failure rates were tabulated.
1 finding from 1 review
Caries experience · Children and adolescents (<18 years) living with HIV (CLWH)
ART was not associated with a significant difference in dental caries experience among CLWH (very low certainty).
1 finding from 1 review
Progression of non-cavitated enamel caries · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric clinic/dental school,…
The review found no eligible studies for this question.
1 finding from 1 review
Intervention not reported
Difference in summary specificity (NMA, Analysis 2)
1 finding from 1 review
Persistent parotid enlargement prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in persistent parotid enlargement between ART regimens (very low certainty).
1 finding from 1 review
Dental caries (association with sugary drinks/sweets consumption) · Children (deciduous and/or permanent dentition) in low- and middle-income countries
Sugary drinks/sweets consumption was associated with about twice the odds of dental caries in LMIC children (OR 2.04, 95% CI 1.59 to 2.60; 7 studies; not GRADE-rated).
1 finding from 1 review
Treatment failure (annual failure rate) · Children with carious primary molars treated by pulpotomy (vital pulp therapy)
Preformed metal crowns had a low annual failure rate (2.4%) in primary molars after pulpotomy, lower than amalgam in the same trial (single high-risk-of-bias RCT; low quality of evidence; not GRADE-rated).
2 findings from 1 review
Progression of non-cavitated enamel caries · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department, dental hospital, France)
The review found no eligible studies for this question.
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; bilayer placement and nanofilled coating were described as improving survival.
1 finding from 1 review
Annual failure rate (%) 32.4%, 13.7%, 18.7%, 13.4% by insertion/coating arm
1 study · 208 participants
GRADE not reported
Dental caries (by severity) · Children or adolescents
One study reported higher median caries severity among CLWH under 12 years; no meta-analytic estimate was pooled.
1 finding from 1 review
Restorative index (RI = f/[d+f]) in the primary dentition · Children in the primary dentition with non-syndromic cleft lip and/or palate (CL/P) and comparable children without CL/P
The restorative index tended to be lower in children with CL/P (3 of 5 studies), indicating a lower proportion of restoratively managed carious teeth; not pooled (narrative; ungraded).
1 finding from 1 review
Pulpal disease (signs/symptoms of pulp necrosis) · Children with dentine caries in primary and permanent teeth
The reported estimate did not show a clear difference in pulpal disease after partial versus complete caries removal (ungraded).
1 finding from 1 review
RR 0.27 [0.05, 1.60]
3 studies
GRADE not reported
Intervention not reported
Difference in summary sensitivity (NMA, Analysis 2)
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of CDH17 (chr8q22.1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of CDH17 was significantly associated with ECC in the TWAS (p = 3.32e-8); genetic association, ungraded.
1 finding from 1 review
Oral cytology (e.g. OralCDx brush biopsy, CytID) vs Reference standard: examination and clinical evaluation by a physician/clinician with specialist knowledge or training (long-term follow-up accepted for those screened negative)
Outcome not reported · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
The review found no eligible studies for this question.
1 finding from 1 review
Oral disease prevalence · Children with leukemia in the United Arab Emirates
Oral problems prevalence was 60%.
1 finding from 1 review
Prevalence 60
1 study
GRADE not reported