What do systematic reviews say?

Vasodilator vs placebo or no treatment

• Vasodilators for women undergoing fertility treatment 2018 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 477 participants
  Very low

Vasodilator vs placebo or no treatment

Vasodilator showed no clear difference in multiple gestation or birth compared with placebo or no treatment (low certainty).

• Vasodilators for women undergoing fertility treatment 2018 · Cochrane Headline outcomes only
  RR 1.15 [0.55, 2.42]
  3 studies · 370 participants
  Low

Vasodilator vs placebo or no treatment

Vasodilator showed no clear difference in spontaneous miscarriage compared with placebo or no treatment (low certainty).

• Vasodilators for women undergoing fertility treatment 2018 · Cochrane Headline outcomes only
  RR 0.83 [0.37, 1.86]
  3 studies · 350 participants
  Low

Vasodilator vs placebo or no treatment

Vasodilator showed no clear difference in ectopic pregnancy compared with placebo or no treatment (low certainty).

• Vasodilators for women undergoing fertility treatment 2018 · Cochrane Headline outcomes only
  RR 1.48 [0.25, 8.69]
  2 studies · 250 participants
  Low

Intervention not reported

It is very uncertain whether the intervention changes live birth Cleavage stage: hCG < 500 IU (very low certainty).

• Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction 2018 · Cochrane Headline outcomes only
  RR 0.76 [0.58, 1.01]
  1 study · 280 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes miscarriage (very low certainty).

• Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction 2018 · Cochrane Headline outcomes only
  RR 1.04 [0.81, 1.35]
  11 studies · 3927 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes clinical pregnancy Cleavage stage: hCG < 500 IU (very low certainty).

• Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction 2018 · Cochrane Headline outcomes only
  RR 0.88 [0.7, 1.1]
  1 study · 280 participants
  Very low

Intervention not reported

• Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction 2018 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 1764 participants
  Very low

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

ART with seminal plasma showed no clear difference in live birth compared with standard ART (IVF, ICSI, and frozen embryo transfer) (low certainty).

• Application of seminal plasma to female genital tract prior to embryo transfer in assisted reproductive technology… 2018 · Cochrane Headline outcomes only
  RR 1.1 [0.86, 1.43]
  3 studies · 948 participants
  Low

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

ART with seminal plasma showed no clear difference in miscarriage compared with standard ART (IVF, ICSI, and frozen embryo transfer) (low certainty).

• Application of seminal plasma to female genital tract prior to embryo transfer in assisted reproductive technology… 2018 · Cochrane Headline outcomes only
  RR 1.01 [0.57, 1.79]
  4 studies · 1209 participants
  Low

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

ART with seminal plasma showed no clear difference in live birth or ongoing pregnancy compared with standard ART (IVF, ICSI, and frozen embryo transfer) (low certainty).

• Application of seminal plasma to female genital tract prior to embryo transfer in assisted reproductive technology… 2018 · Cochrane Headline outcomes only
  RR 1.19 [0.95, 1.49]
  4 studies · 1178 participants
  Low

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

It is very uncertain whether ART with seminal plasma changes clinical pregnancy compared with standard ART (IVF, ICSI, and frozen embryo transfer) (very low certainty).

• Application of seminal plasma to female genital tract prior to embryo transfer in assisted reproductive technology… 2018 · Cochrane Headline outcomes only
  RR 1.15 [1.01, 1.31]
  10 studies · 2768 participants
  Very low

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

ART with seminal plasma showed no clear difference in multiple pregnancy compared with standard ART (IVF, ICSI, and frozen embryo transfer) (low certainty).

• Application of seminal plasma to female genital tract prior to embryo transfer in assisted reproductive technology… 2018 · Cochrane Headline outcomes only
  RR 1.11 [0.76, 1.64]
  5 studies · 1642 participants
  Low

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

It is very uncertain whether ART with seminal plasma changes ectopic pregnancy compared with standard ART (IVF, ICSI, and frozen embryo transfer) (very low certainty).

• Application of seminal plasma to female genital tract prior to embryo transfer in assisted reproductive technology… 2018 · Cochrane Headline outcomes only
  RR 1.59 [0.2, 12.78]
  5 studies · 1521 participants
  Very low

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

The review found no eligible studies for this question.

• Application of seminal plasma to female genital tract prior to embryo transfer in assisted reproductive technology… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metabolomics vs non metabolomics

Metabolomics showed no clear difference in live birth rate (Delivery of a live fetus after 20 completed weeks… compared with non metabolomics (low certainty).

• Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies 2018 · Cochrane Headline outcomes only
  OR 0.99 [0.69, 1.44]
  3 studies · 597 participants
  Low

Metabolomics vs non metabolomics

Metabolomics showed no clear difference in live birth rate or ongoing pregnancy (Delivery of a live fetus after… compared with non metabolomics (low certainty).

• Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies 2018 · Cochrane Headline outcomes only
  OR 1.02 [0.77, 1.35]
  4 studies · 924 participants
  Low

Metabolomics vs non metabolomics

Metabolomics showed no clear difference in miscarriage (Loss of pregnancy before 20 completed weeks of gestation) compared with non metabolomics (low certainty).

• Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies 2018 · Cochrane Headline outcomes only
  OR 1.18 [0.77, 1.82]
  3 studies · 869 participants
  Low

Metabolomics vs non metabolomics

Metabolomics showed no clear difference in clinical pregnancy (Presence of a fetal heart on ultrasound scan at… compared with non metabolomics (low certainty).

• Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies 2018 · Cochrane Headline outcomes only
  OR 1.11 [0.85, 1.45]
  4 studies · 924 participants
  Low

Metabolomics vs non metabolomics

Metabolomics may leads to higher cancellation (Exclusion of a patient after recruitment) compared with non metabolomics (low certainty).

• Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies 2018 · Cochrane Headline outcomes only
  OR 1.78 [1.18, 2.69]
  2 studies · 744 participants
  Low