Treatment failure (annual failure rate) · Children with previously unrestored, vital carious lesions in primary teeth (no pulp therapy); aged 1.5-11 years
Metal-reinforced GIC had a high annual failure rate (29.9%) in a single RCT; low quality of evidence (ungraded).
1 finding from 1 review
Oral health-related quality of life · Children with dental caries
SDF plus fluoride varnish did not significantly differ from ART plus fluoride varnish for oral health-related quality of life (MD 0.16, 95% CI -0.1 to 0.42; ungraded).
1 finding from 1 review
Low SES prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries
About 36% of children with caries in LMICs were of low SES (pooled prevalence 0.359, 95% CI 0.167 to 0.578; 4 studies; not GRADE-rated).
1 finding from 1 review
Oral candidiasis · Children and adolescents living with HIV on ART/HAART
Oral candidiasis prevalence differed by ART duration (OR 17.93, 95% CI 3.69 to 83.12).
1 finding from 1 review
Sex/gender differences in fluoride intake or dental-care-product contribution · Participants stratified by sex/gender (especially young children)
No study has taken sex/gender into account when assessing fluoride intake, especially in young children.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Restoration survival · Children with decayed primary molar teeth
Multi-surface ART/HVGIC restorations had lower reported survival (49% at 3 years) than single-surface restorations (ungraded).
1 finding from 1 review
Survival rate (%) 49
9 studies
GRADE not reported
Periodontal disease prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
ART was not associated with a significant difference in periodontal disease prevalence among CLWH (very low certainty).
1 finding from 1 review
KEGG pathway associations · Participants in oral 16S rRNA caries microbiome studies
Phosphonate and phosphinate metabolism and glyoxylate and dicarboxylate metabolism had the lowest reported adjusted P values (0.04); no pooled effect estimate was reported.
1 finding from 1 review
Kaposi's sarcoma prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Kaposi's sarcoma was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.00 [0.00, 0.03]
Studies not reported
Very low
Choking · Healthy children aged 6–24 months in Western industrialized countries
No statistically significant difference in choking events between BLW/BLISS and TCF was reported.
1 finding from 1 review
no estimate extracted
6 studies
GRADE not reported
Root caries prediction accuracy · Dental images of human beings
The review reported 97.1% accuracy for root caries prediction in Hung et al. (Ungraded).
1 finding from 1 review
Kaposi's sarcoma prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in kaposi's sarcoma between ART regimens (very low certainty).
1 finding from 1 review
Food purchasing · Children and adolescents (general population, aged under 20 years)
Food marketing showed no clear association with food purchasing by or for children (very low certainty).
1 finding from 1 review
No clear evidence of association with purchasing. Vote counting: any association of public health harm in 2 of 5 studies (40%; 95% CI, 7.3%-83.0%); all 3 observational NRSs found an association (2 harm, 1 benefit),…
5 studies
Very low
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
ART was associated with lower oral candidiasis prevalence.
1 finding from 1 review
OR 0.35 [0.19, 0.63]
7 studies
Very low
Intervention not reported
Difference in summary specificity (NMA, Analysis 2)
1 finding from 1 review
Contribution to total daily fluoride intake · adults
For adults in low-fluoridated areas, the mean contribution was 95%.
1 finding from 1 review
Recurrent oral ulceration prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in recurrent oral ulceration between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 1.50 [0.72, 3.13]
Studies not reported
Very low
Hypertension (later in life) · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
No eligible studies examined the influence of complementary feeding practices on later hypertension; this is an evidence gap.
1 finding from 1 review
Accuracy advantage in test case 2 · Dental images of human beings
The review reported a 52% accuracy advantage in Patil test case 2 (Ungraded).
2 findings from 1 review
Dental caries prevalence · Children (deciduous and/or permanent dentition) in low- and middle-income countries
About 39% of children in LMICs had dental caries (pooled prevalence 0.387, 95% CI 0.284 to 0.495; 11 studies; very high heterogeneity I2=99%; not GRADE-rated).
1 finding from 1 review