Accuracy advantage in test case 3 · Dental images of human beings
The review reported a 6.30% accuracy advantage in Patil test case 3 (Ungraded).
1 finding from 1 review
Ulcerative stomatitis · Children or adolescents
One study found significantly higher ulcerative stomatitis among CLWH on ART (OR 28.59, 95% CI 1.67 to 490.32), though the estimate is very imprecise.
1 finding from 1 review
Plaque · Adults and children (predominantly adults; one study in children), with natural dentition
Xylitol sugar-free gum significantly reduced plaque quantity versus no-gum/control (SMD -0.743, 95% CI -1.148 to -0.338), with high heterogeneity (I2 = 86.0%; ungraded).
1 finding from 1 review
Enamel caries proportion · European adolescents aged 17 years
Pooled enamel caries proportion was 0.58.
1 finding from 1 review
Early childhood caries (ECC) · Healthy children under 6 years in South Africa
No significant difference in caries odds was found between mixed breast-and-bottle-fed and bottle-fed-only children (meta-analysis reported no difference; pooled estimate in an unavailable supplementary figure; not GRADE-rated).
1 finding from 1 review
Secondary caries · Patients with permanent dentition in need of restorations (all cavity types: Black's Class I, II, V, and non-carious cervical lesions)
Pooled across follow-up periods, ion-releasing (GIC) and resin composite restorations show no significant difference in secondary caries (RD -0.00, 95% CI -0.01 to 0.00; not separately GRADE-rated).
6 findings from 1 review
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomesOverall (1 year, 18 months-2 years, and 3 years pooled) · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD -0.00 [-0.01, 0.00]
12 studies · 3085 participants
GRADE not reported
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes18 months-2 years · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD -0.00 [-0.01, 0.01]
8 studies · 1087 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes1 year · University, private practice, primary school, and multicenter settings · All types of cavities
RD -0.00 [-0.01, 0.01]
12 studies · 1677 participants
Low
Show 3 more findings
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes3 years · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD 0.00 [-0.02, 0.02]
3 studies · 321 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes1 year · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD -0.00 [-0.01, 0.01]
12 studies · 1677 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes18 months to 2 years · University, private practice, primary school, and multicenter settings · All types of cavities
RD -0.00 [-0.01, 0.01]
8 studies · 1087 participants
Low
Plaque index (PI) / oral hygiene · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs)
School-based interventions may reduce dental plaque scores (SMD -0.32, favouring intervention), but the certainty of evidence is very low.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of TAS2R43 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of TAS2R43 was significantly associated with ECC in the TWAS (p = 8.78e-8); genetic association, ungraded.
1 finding from 1 review
Intervention not reported
Difference in summary sensitivity (NMA, Analysis 2)
1 finding from 1 review
Progression of non-cavitated enamel caries · 'Healthy' children with caries-free second primary molars, aged 3-5 years (schools and kindergartens, India and China)
The review found no eligible studies for this question.
1 finding from 1 review
Differential microbial abundance / taxa predictive of caries · Individuals providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples; 2016 samples from 19 studies (mixed children and…
A group of genera/species (notably Selenomonas, Aggregatibacter, Actinomyces, Treponema) was predictive of caries, whereas Streptococcus was not (ungraded).
1 finding from 1 review
Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. 2022 All outcomesOral cavity microbiome (saliva and supragingival plaque samples); pooled across 19 international studies
Mean-decrease-accuracy discriminating taxa: Capnocytophaga HMT-338, Lactobacillus panis, Treponema HMT-230, Bifidobacterium longum, Delftia acidovorans, Staphylococcus schleiferi; higher log2FC in caries: Selenomonas HMT-146, Aggregatibacter actinomycetemcomitans, Actinomyces HMT-896, Treponema HMT-257; Streptococcus not predictive
19 studies · 2016 participants
GRADE not reported
Restoration failure · Children with carious primary teeth after vital or non-vital pulp therapy
In one RCT, composite resin had an annual failure rate of 0% after 2 years.
1 finding from 1 review
Development of >=1 new carious lesion (caries incidence) · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department, dental hospital, France)
2 findings from 1 review
Weight gain · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
Narratively, restrictive NRCF style tended to favor excess weight and coercive/pressuring style tended to favor lower weight (3 of 5 studies each; ungraded).
1 finding from 1 review
Intervention not reported
Difference in summary specificity (NMA, Analysis 2)
1 finding from 1 review
Correlation between daily urinary fluoride excretion (DUFE) and fluoride intake · Children and adults with 24-h urinary fluoride monitoring (9 studies reporting both intake and urine; Table 2)
Daily urinary fluoride excretion was not correlated with total daily fluoride intake or with fluoride intake from toothpaste (R2 < 0.07), based on nine studies (ungraded).
1 finding from 1 review
Dental caries prevalence · Children aged 12 years (plus or minus one year) in Africa
The pooled dental-caries prevalence was 0.3657 (95% CI 0.3065 to 0.4250); GRADE was not reported.
2 findings from 1 review
Prevalence 0.3657 [0.3065, 0.4250]
Studies not reported
GRADE not reported
Prevalence 0.356 [0.294, 0.417]
Studies not reported
GRADE not reported
Intervention not reported
Difference in summary sensitivity (NMA, Analysis 2)
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of SMIM10L1 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of SMIM10L1 was significantly associated with ECC in the TWAS (p = 1.70e-7); genetic association, ungraded.
1 finding from 1 review
Alpha diversity (Chao1, Observed, Shannon) · Adults providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples
In adults, caries-vs-health alpha diversity differed for the Shannon index but not Chao1/Observed (ungraded).
1 finding from 1 review