Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether pentoxifylline changes burning sensation (VAS 0-100) compared with placebo or no active treatment (very low certainty).
1 finding from 1 review
Prevalence of ICLs (proportion of subjects affected) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances
Around 57% of patients had ICLs during or after fixed orthodontic treatment (pooled prevalence 0.57, 95% CI 0.48-0.65; very low certainty; very high heterogeneity).
1 finding from 1 review
Any adverse effect related to aPDT · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care
1 finding from 1 review
Risk with control: In 1 study, 1 participant had an abscess (not specified if this was related to aPDT). In 2 other studies, no adverse effects of aPDT were observed. Number of participants (studies): 134 (3 RCTs).…
3 studies · 134 participants
Moderate
SiC30 index score · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
Package of oral health education/promotion including oral hygiene… led to lower siC30 index score compared with standard care; GRADE not reported.
1 finding from 1 review
Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
The review found no eligible studies for this question.
1 finding from 1 review
Perceived need for surgery in adulthood · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask may leads to higher perceived need for surgery in adulthood compared with untreated control (no treatment) (low certainty).
1 finding from 1 review
Periodontal conditions (gingival inflammation, bleeding on probing, probing depth, clinical attachment loss) · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)
Narrative synthesis of 6 studies suggests children/adolescents with CLP have poorer periodontal status (higher gingival and plaque indices, deeper probing, more bleeding and attachment loss) and harbor periodontopathogens; no pooled estimate and the evidence is ungraded.
1 finding from 1 review
Crown caries · adults
Periodontitis was associated with a small increase in crown caries odds (OR 1.03).
1 finding from 1 review
White spot lesion development (QLF: mineral loss, lesion area/depth, new lesions) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
A single RCT found the one-step adhesive without a primer (GC Ortho Connect) produced more and more severe white spot lesions than conventional multi-step systems (ungraded).
1 finding from 1 review
Dental caries · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK Biobank European…
Meta-analysis identified a novel genome-wide-significant locus for dental caries at rs4801882 in SIGLEC5 (P=1.71E-08); ungraded.
1 finding from 1 review
d/D dft/DFT or dmft/DMFT score differences · Children and adults with primary or permanent dentition
Eight studies calculated caries-score differences; six reported no significant difference, one underestimation, and one overestimation with teledentistry.
1 finding from 1 review
no estimate extracted
8 studies
GRADE not reported
Economic: direct costs · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
The review found no eligible studies for this question.
1 finding from 1 review
Root resorption · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
The review found no eligible studies for this question.
1 finding from 1 review
Patient discomfort · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
Periodontitis (clinical attachment loss) · Adults in case-control studies (oral cancer patients vs healthy controls)
Clinical attachment loss was significantly greater in oral cancer patients than controls (SMD 1.94, 95% CI 0.22-3.66), though heterogeneity was very high (I2=96.7%); ungraded.
1 finding from 1 review
Pain at 7 days · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
1 finding from 1 review
The median pain at 7 days in the control group was 0 (range 0 to 3); the median pain at 7 days in the intervention group was the same (median 0, range 0 to 1). P = 0.673 (Mann-Whitney U).
1 study · 72 participants
Low
Bracket (bond) failure · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Clearfil Protect Bond showed no difference in bracket failure, with certainty not graded.
1 finding from 1 review
No statistically significant difference in bond failure rates was observed between quadrants bonded with Clearfil (CF) and those bonded with the conventional primer (p = 0.316).
1 study · 35 participants
GRADE not reported
Patient discomfort · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
Intervention not reported
Dental caries (early childhood caries)
1 finding from 1 review
AOR 6.7
1 study
GRADE not reported
Dental caries prevalence · Nigerian individuals, including children and adults, with primary or permanent dentition
High-frequency sugar consumption was associated with 18% higher but non-significant odds of dental caries in Nigeria (OR 1.18, 95% CI 0.87 to 1.59; I2=36%; ungraded).
1 finding from 1 review